SynthesisPloS one2021
COVID-19 and cause of pregnancy loss during the pandemic: A systematic review.
Synthesis in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- COVID-19 in pregnant women: a systematic review and meta-analysis on the risk and prevalence of pregnancy loss.Human reproduction update · 2024Pooled it
- Efficacy and safety of therapies for COVID-19 in pregnancy: a systematic review and meta-analysis.BMC infectious diseases · 2023Pooled it
- SARS-CoV-2 Vaccines during Pregnancy and Breastfeeding: A Systematic Review of Maternal and Neonatal Outcomes.Viruses · 2022Pooled it
- Remdesivir Use During Pregnancy: Findings From the Prospective COVID-19 International Drug Pregnancy Registry and Narrative Literature Review.Journal of pregnancy · 2026Review
- Laboratory changes and clinical correlates of disease severity in hospitalized pregnant women with COVID-19.Annals of medicine and surgery (2012) · 2025Article
- Impact of SARS-CoV-2 Infection on the Course of Pregnancy and Birth After Assisted Reproduction.Geburtshilfe und Frauenheilkunde · 2025Article
- The impact of COVID-19 infection on ART outcomes: a multicenter retrospective cohort study.Journal of ovarian research · 2025Article
- Evaluating miscarriage incidence after COVID-19 vaccination.Scientific reports · 2025Article
- The challenges of prenatal care services during the COVID-19 pandemic: qualitative evidence of primary health care providers' perspective in Iran.BMC primary care · 2025Article
- Incidence of Spontaneous Abortions During the COVID-19 Pandemic in a Regional County Hospital in Romania: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Effects of the COVID-19 pandemic on maternal-fetal outcomes in a nonepidemic designated hospital: a retrospective study and clinical experience summary.BMC infectious diseases · 2024Article
- Maternal and Fetal Outcomes of COVID-19 According to the Trimester of Diagnosis: A Cross-Sectional Prospective Study in a Tertiary University Hospital.Journal of clinical medicine · 2024Article
- Identifying the Risk Factors of Adverse Pregnancy Outcomes among Women with COVID-19: A Population-Based Case-Control Study in Southern Iran.Journal of caring sciences · 2024Article
- Assisted reproduction after SARS-CoV-2-infection: results of a single-center cohort-study.Archives of gynecology and obstetrics · 2024Article
- Retrospective Analysis of the Impact of SARS-CoV-2 (COVID-19) on Pregnancy and Neonatal Outcomes.Journal of pregnancy · 2024Article
- Association of placental histopathological findings with COVID-19 and its predictive factors.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024Article
- Case report: Complex evaluation of coagulation, fibrinolysis and inflammatory cytokines in a SARS-CoV-2 infected pregnant woman with fetal loss.Frontiers in immunology · 2024Article
- Effects of COVID-19 vaccination on human fertility: a post-pandemic literature review.Annals of medicine · 2023Review
- Association between COVID-19 Infection and Miscarriages, What We Really Know?Diseases (Basel, Switzerland) · 2023Review
- COVID-19 Vaccine Safety Surveillance in Early Pregnancy in the United States: Design Factors Affecting the Association Between Vaccine and Spontaneous Abortion.American journal of epidemiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe association between Coronavirus Disease 2019 (COVID-19) and abortion has been debated since the beginning of the COVID-19 pandemic. We aimed to conduct this systematic review to understand better the potential effects of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) on fetal loss in infected mothers presented with abortion following this infection.
methodsWe included articles published in PubMed/Medline, Web of Science, clinicaltrials.gov, and Embase databases in 2019 and 2020 through a comprehensive search via appropriate keywords, including COVID-19 and abortion synonyms. All studies with the abortion data in COVID-19 confirmed pregnant females were collected.
resultsOut of 208 potentially relevant articles, 11 articles were eligible to include in the systematic review. The included reports were published because of the following reasons: (1) First-trimester miscarriage; (2) Late miscarriage; (3) complication of COVID-19 infection in pregnancy; (4) COVID-19 disease in artificial pregnancy. First-trimester abortion was found in 5 studies, and second-trimester abortion in 7 studies. Two patients acquired infection during the hospital stay while they were referred for abortion. Reports related to abortion in pregnant females with COVID-19 show that most miscarriages due to COVID-19 in the first trimester were due to placental insufficiency.
conclusionsThere is an increased risk of abortion in mothers with a positive test result of SARS-CoV-2, which several case reports and case series have identified during the pandemic. Placental inflammation during the viral infection may result in fetal growth retardation and induce abortion. There has not been any consistent evidence of vertical transmission of the virus from mother to fetus, which requires further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.