ArticlePloS one2021
Functional limitations in people with multimorbidity and the association with mental health conditions: Baseline data from the Canadian Longitudinal Study on Aging (CLSA).
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Multimorbidity and the risk of depression: a systematic review of cohort studies.Journal of global health · 2026Pooled it
- Longitudinal Patterns of Within- and Cross-Domain Multimorbidity Across Physical, Psychological, and Cognitive Conditions in China and the United States: The Role of Socioeconomic and Healthcare Inequalities.Healthcare (Basel, Switzerland) · 2026Article
- Multimorbidity, health service use, and health insurance by socioeconomic groups in 31 countries: A multi-cohort study.PLoS medicine · 2026Article
- Article
- Multimorbidity quantification from the perspective of precision management: challenges and strategies.Annals of medicine · 2025Review
- The assimilation affects research from three days' social facilitation of eating by using whole network autocorrelation analysis plus multilevel linear modeling: a normative analysis based on prospective cohort study data in the UK.Population health metrics · 2025Article
- Dynamics of multimorbidity patterns in older population across socioeconomic areas.Communications medicine · 2025Article
- Dynamic cross-lagged effects between healthy lifestyles and multimorbidity among middle-aged and older adults in China.BMC public health · 2025Article
- Increased Depressive and Anxiety Symptoms Predict Increased Severity of Functional Impairment After Five Years: A Nationally Representative Retrospective Cohort Study.Journal of patient-centered research and reviews · 2025Article
- Uncovering bridging diseases in complex multimorbidity pathways: A network science approach.PloS one · 2025Article
- Limited Physical Functioning in United States Adults with Arthritis: Findings from the 2021 Medical Expenditure Panel Survey.Diseases (Basel, Switzerland) · 2024Article
- Multimorbidity in Incident Heart Failure: Characterisation and Impact on 1-Year Outcomes.Journal of clinical medicine · 2024Article
- Article
- Relationship between multimorbidity, functional limitation, and quality of life among middle-aged and older adults: findings from the longitudinal analysis of the 2013-2020 Survey of Health, Ageing, and Retirement in Europe (SHARE).Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Epidemiology, mortality, and health service use of local-level multimorbidity patterns in South Spain.Nature communications · 2023Article
- Relationship between Perceived Pain Interference and Poor Psychological Wellbeing among United States Adults.Behavioral sciences (Basel, Switzerland) · 2023Article
- Article
- Multimorbidity Patterns and Associations with Gait, Balance and Lower Extremity Muscle Function in the Elderly: A Cross-Sectional Study in Northwest China.International journal of general medicine · 2023Article
- Association between activities of daily living and depressive symptoms among older adults in China: evidence from the CHARLS.Frontiers in public health · 2023Article
- Practical pathway for the management of depression in the workplace: a Canadian perspective.Frontiers in psychiatry · 2023Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
introductionIncreasing multimorbidity is often associated with declining physical functioning, with some studies showing a disproportionate impact on functioning when mental health conditions are present. More research is needed because most multimorbidity studies exclude mental health conditions.
objectivesThis study aims to improve our understanding of the association between functional limitation and multimorbidity, including a comparison of those with multimorbidity that includes versus excludes mental health conditions.
methodsThis is a population-based, cross-sectional analysis of data from The Canadian Longitudinal Study on Aging. Functional limitation was defined as the presence of any of 14 activities of daily living (ADLs) or instrumental activities of daily living (IADLs). Multimorbidity, measured by the number of chronic conditions, included mood and anxiety disorders. Logistic regression explored the association between multimorbidity (with and without mental health conditions) and functional limitation. Factor analysis identified common condition clusters to help understand clinical complexity in those with mood/anxiety disorders and the potential influences on functional limitation.
resultsThere were 51,338 participants, with a similar proportion of men and women (49% versus 51%) and 42% age 65 years or older. Fifteen percent (15%) had no chronic conditions and 17% had 5+. Ten percent (10%) reported at least one ADL or IADL limitation. Odds ratios (ORs) for functional limitation increased with multimorbidity and were generally higher for those with versus without mental health conditions (e.g., ORs from 1 to 5+ chronic conditions increased 1.9 to 15.8 for those with mood/anxiety disorders versus 1.8 to 10.2 for those without). Factor analysis showed that mood/anxiety conditions clustered with somatic conditions (e.g., migraines, bowel/gastrointestinal disorders).
conclusionThis study found higher odds of functional limitation for those with multimorbidity that included versus excluded mental health conditions, at all levels of multimorbidity. It highlights the need for concurrent management of mental and physical comorbidities to prevent functional limitations and future decline. This approach is aligned with the NICE clinical assessment and management guidelines for people with multimorbidity.
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