ArticlePLoS neglected tropical diseases2021
Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore.
Article in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Quantifying, Understanding, and Correcting for Delays in Routine Dengue Case Reporting in the Americas.The American journal of tropical medicine and hygiene · 2026Article
- An improved ovitrap-based surveillance framework: facilitating cost-efficient monitoring and efficacy assessment of integrated vector management strategies for dengue outbreak control.Parasites & vectors · 2025Article
- Could prophylactic antivirals reduce dengue incidence in a high-prevalence endemic area?PLoS neglected tropical diseases · 2024Article
- A phylogenetic study of dengue virus in urban Vietnam shows long-term persistence of endemic strains.Virus evolution · 2023Article
- Using models and maps to inform Target Product Profiles and Preferred Product Characteristics: the example ofGates open research · 2023Article
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Authors and funding
12 authors.
Funding
Abstract
backgroundTargeting interventions to areas that have recently experienced cases of disease is one strategy to contain outbreaks of infectious disease. Such case-area targeted interventions (CATI) have become an increasingly popular approach for dengue control but there is little evidence to suggest how precisely targeted or how recent cases need to be, to mount an effective response. The growing interest in the development of prophylactic and therapeutic drugs for dengue has also given new relevance for CATI strategies to interrupt transmission or deliver early treatment. METHODS/PRINCIPAL
findingsHere we develop a patch-based mathematical model of spatial dengue spread and fit it to spatiotemporal datasets from Singapore. Simulations from this model suggest CATI strategies could be effective, particularly if used in lower density areas. To maximise effectiveness, increasing the size of the radius around an index case should be prioritised even if it results in delays in the intervention being applied. This is partially because large intervention radii ensure individuals receive multiple and regular rounds of drug dosing or vector control, and thus boost overall coverage. Given equivalent efficacy, CATIs using prophylactic drugs are predicted to be more effective than adult mosquito-killing vector control methods and may even offer the possibility of interrupting individual chains of transmission if rapidly deployed. CATI strategies quickly lose their effectiveness if baseline transmission increases or case detection rates fall. CONCLUSIONS/SIGNIFICANCE: These results suggest CATI strategies can play an important role in dengue control but are likely to be most relevant for low transmission areas where high coverage of other non-reactive interventions already exists. Controlled field trials are needed to assess the field efficacy and practical constraints of large operational CATI strategies.
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