Evidence map›Paper›PMID 34379508›Full record

ArticleJournal of virology2021

Paramyxovirus-Like Particles as Protein Delivery Vehicles.

Santosh Panthi, Phuong Tieu Schmitt, F Jeffrey Lorenz, Brent A Stanfield, Anthony P Schmitt

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Santosh Panthi *Department of Veterinary and Biomedical Sciences, The Pennsylvania State Universitygrid.29857.31, University Park, Pennsylvania, USA.
Phuong Tieu Schmitt *Department of Veterinary and Biomedical Sciences, The Pennsylvania State Universitygrid.29857.31, University Park, Pennsylvania, USA.
F Jeffrey LorenzDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State Universitygrid.29857.31, University Park, Pennsylvania, USA.
Brent A StanfieldSchool of Veterinary Medicine, Louisiana State Universitygrid.64337.35, Baton Rouge, Louisiana, USA.
Anthony P SchmittDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State Universitygrid.29857.31, University Park, Pennsylvania, USA.ORCID 0000-0001-9272-058X
Pennsylvania State University · USLouisiana State University · US

Funding

Mechanistic studies of M and NP interactions of paramyxovirusesR21AI121880 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI SCHMITT, ANTHONY P · 2016 to 2017
$430k
BioStrategies Partners Germinator ProgramHHS | National Institutes of Health (NIH) AI121880NIAID NIH HHS R21 AI121880PSU College of Ag. Entrepreneurship and Innovation Fellowship awardPSU College of Ag. RAIN award 0400431U.S. Department of Agriculture (USDA) PEN04605Ximus Biosciences 229004
6 · The paper itself

Abstract

We have developed a flexible platform for delivery of proteins to target cell interiors using paramyxovirus-like particles. The key enabling feature is an appendage, 15 to 30 amino acid residues in length, that is added to cargo proteins and that induces them to bind to the viral matrix (M) protein during virus-like particle (VLP) assembly. The cargo is then incorporated within the VLPs as they bud, using the same interactions that normally direct viral genome packaging. The appendage can also serve as an epitope tag for cargo detection using a nucleocapsid (NP) protein-specific monoclonal antibody. Using this approach, we generated

Indexed as

Drug Delivery SystemsGenetic EngineeringHumansLuciferases, RenillaNucleocapsidParamyxoviridaeViral Matrix ProteinsVirionVirus AssemblyLuciferases, RenillaViral Matrix Proteinsnucleocapsidpackagingparamyxovirusprotein deliveryVLP

Identifiers

PMID34379508
PMCPMC8475536
OpenAlexW4206403056

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.