Evidence map›Paper›PMID 34379433›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Blood-Brain Barrier Crossing Renin-Angiotensin System Drugs: Considerations for Dementia and Cognitive Decline.

Lidia Glodzik, Monica M Santisteban

Abstract readEditorialComment
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Current updates on latest basic research of scientific relevance in hypertensive dementia.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  3. Unlocking Novel Therapeutic Potential of Angiotensin II Receptor Blockers.International journal of molecular sciences · 2025
    Review
  4. Review
  5. Review
  6. Trajectory of Cardiogenic Dementia: A New Perspective.Journal of cellular and molecular medicine · 2025
    Review
  7. Cerebral amyloid angiopathy: a narrative review.Frontiers in aging neuroscience · 2025
    Review
  8. Review
  9. Article
  10. Review
  11. The Renin Angiotensin System as a Therapeutic Target in Traumatic Brain Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  12. Article
  13. Review
  14. Is it possible to prevent cognitive decline among middle-aged and older hypertensive individuals?Hypertension research : official journal of the Japanese Society of Hypertension · 2022
    Article
  15. Review
  16. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Lidia GlodzikBrain Health and Imaging Institute (L.G.), Weill Cornell Medicine, New York, NY.
Monica M SantistebanBrain and Mind Research Institute (M.M.S.), Weill Cornell Medicine, New York, NY.

Funding

Hypertension, brain clearance and markers of neurodegenerationR01NS104364 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GLODZIK, LIDIA · 2018 to 2022
$3.7M
Neuroimmune Mechanisms of Cognitive Impairment in Salt-sensitive HypertensionK22NS123507 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI SANTISTEBAN FREEMAN, MONICA M · 2021 to 2025
$982k
NINDS NIH HHS K22 NS123507NINDS NIH HHS R01 NS104364
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cognitive DysfunctionDementiaPharmaceutical PreparationsBlood-Brain BarrierHumansRenin-Angiotensin SystemPharmaceutical Preparations

Identifiers

PMID34379433
PMCPMC9125564

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.