Evidence map›Paper›PMID 34379430›Full record

ArticleThe journal of physical chemistry. B2021

Submillisecond Conformational Transitions of Short Single-Stranded DNA Lattices by Photon Correlation Single-Molecule Förster Resonance Energy Transfer.

Brett Israels, Claire S Albrecht, Anson Dang, Megan Barney, Peter H von Hippel, Andrew H Marcus

Open access · greenAbstract read
In one paragraph

Article in The journal of physical chemistry. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Evidence of a Three-State Mechanism in DNA Hairpin Folding.Journal of the American Chemical Society · 2025
    Article
  4. Article
  5. Review
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  11. Review
  12. Article
  13. Disruption of energetic and dynamic base pairing cooperativity in DNA duplexes by an abasic site.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Studies of DNA breathing in exciton-coupled (iCy3)Proceedings of SPIE--the International Society for Optical Engineering
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Brett IsraelsDepartment of Chemistry and Biochemistry, Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403, United States.
Claire S AlbrechtDepartment of Physics, Center for Optical, Molecular and Quantum Science, Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403, United States.
Anson DangDepartment of Chemistry and Biochemistry, Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403, United States.
Megan BarneyDepartment of Chemistry and Biochemistry, Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403, United States.
Peter H von HippelDepartment of Chemistry and Biochemistry, Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403, United States.
Andrew H MarcusDepartment of Chemistry and Biochemistry, Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403, United States.ORCID 0000-0003-2109-327X
University of Oregon · US

Funding

STRUCTURE AND RELATIONS OF PROTEINS AND NUCLEIC ACIDSR01GM015792 · NIGMS · UNIVERSITY OF OREGON · PI MARCUS, ANDREW HADLEY · 1985 to 2025
$10.2M
MOLECULAR BIOLOGY AND BIOPHYSICST32GM007759 · NIGMS · UNIVERSITY OF OREGON · PI NOLEN, BRADLEY J · 1985 to 2021
$8.5M
MOLECULAR INTERACTION IN T4 DNA REPLICATION COMPLEXR01GM029158 · NIGMS · UNIVERSITY OF OREGON · PI VON HIPPEL, PETER HANS · 1985 to 2003
$1.2M
NIGMS NIH HHS R01 GM015792NIGMS NIH HHS R01 GM029158NIGMS NIH HHS T32 GM007759
6 · The paper itself

Abstract

Thermally driven conformational fluctuations (or "breathing") of DNA play important roles in the function and regulation of the "macromolecular machinery of genome expression." Fluctuations in double-stranded (ds) DNA are involved in the transient exposure of pathways to protein binding sites within the DNA framework, leading to the binding of regulatory proteins to single-stranded (ss) DNA templates. These interactions often require that the ssDNA sequences, as well as the proteins involved, assume transient conformations critical for successful binding. Here, we use microsecond-resolved single-molecule Förster resonance energy transfer (smFRET) experiments to investigate the backbone fluctuations of short [oligo(dT)

Indexed as

DNA, Single-StrandedFluorescence Resonance Energy TransferDNA-Binding ProteinsDNA ReplicationNucleic Acid ConformationProtein BindingDNA-Binding ProteinsDNA, Single-Stranded

Identifiers

PMID34379430
PMCPMC8744481
OpenAlexW3189730287

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.