Evidence map›Paper›PMID 34379304›Full record

ArticleAdvances in therapy2021

Cost-Effectiveness Analysis of Remdesivir Treatment in COVID-19 Patients Requiring Low-Flow Oxygen Therapy: Payer Perspective in Turkey.

Ergun Oksuz, Simten Malhan, Mustafa Sait Gonen, Zekayi Kutlubay, Yilmaz Keskindemirci, James Jarrett, Toros Sahin, Gokcem Ozcagli, Ahmet Bilgic, Merve Ozlem Bibilik and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Advances in therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 7 pooled it
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 7 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  8. Trial
  9. Evidence of quality of life for hospitalised patients with COVID-19: a scoping review.Health technology assessment (Winchester, England) · 2024
    Article
  10. Review
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  16. A comprehensive review on efficient approaches for combating coronaviruses.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Ergun OksuzDepartment of Family Medicine, Faculty of Medicine, Baskent University, Baglica Kampusu, Etimesgut, Ankara, Turkey. eoksuz@baskent.edu.tr.ORCID 0000-0002-5723-5965
Simten MalhanDepartment of Health Care Management, Faculty of Health Sciences, Baskent University, Ankara, Turkey.ORCID 0000-0001-9853-4753
Mustafa Sait GonenCerrahpasa Medical School, Istanbul University, Istanbul, Turkey.ORCID 0000-0002-1089-623X
Zekayi KutlubayCerrahpasa Medical School Hospital, Istanbul University, Istanbul, Turkey.ORCID 0000-0003-0809-1624
Yilmaz KeskindemirciIstanbul University Hospitals, Istanbul, Turkey.ORCID 0000-0003-3637-0620
James JarrettHEOR, Global Value and Access Europe, Gilead Sciences, Foster City, CA, USA.
Toros SahinGilead Sciences Turkey, Istanbul, Turkey.
Gokcem OzcagliGilead Sciences Turkey, Istanbul, Turkey.
Ahmet BilgicGilead Sciences Turkey, Istanbul, Turkey.
Merve Ozlem BibilikGilead Sciences Turkey, Istanbul, Turkey.
Fehmi TabakDepartment of Infectious Disease, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.ORCID 0000-0001-8632-2825
Istanbul University · TRBaşkent University · TRGilead Sciences (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study aims to evaluate the cost-effectiveness of remdesivir compared to other existing therapies (SoC) in Turkey to treat COVID-19 patients hospitalized with < 94% saturation and low-flow oxygen therapy (LFOT) requirement.

methodsWe compared remdesivir as the treatment for COVID-19 with the treatments in the Turkish treatment guidelines. Analyses were performed using data from 78 hospitalized COVID-19 patients with SpO

resultsIn the remdesivir arm, the length of hospital stay (LOS) was 3 days shorter than the SOC. The low ventilator requirement in the remdesivir arm was one factor that decreased the QALY disutility value. In patients who were transferred to intensive care unit (ICU) from the ward, the mean LOS was 17.3 days (SD 13.6), and the mean cost of stay was USD 155.3/day (SD 168.0), while in patients who were admitted to ICU at baseline, the mean LOS was 13.1 days (SD 13.7), and the mean cost of stay was USD 207.9/day (SD 133.6). The mean cost of episode per patient was USD 3461.1 (SD 2259.8) in the remdesivir arm and USD 3538.9 (SD 3296.0) in the SOC arm. Incremental QALYs were estimated at 0.174. Remdesivir treatment was determined to be cost saving vs. SoC.

conclusionsRemdesivir, which results in shorter LOS and lower rates of intubation requirements in ICU patients than existing therapies, is associated with higher QALYs and lower costs, dominating SoC in patients with SpO

Indexed as

COVID-19 Drug TreatmentAdenosine MonophosphateAlanineCost-Benefit AnalysisHumansOxygenSARS-CoV-2TurkeyAdenosine MonophosphateAlanineOxygenremdesivirCost-effectivenessCOVID-19Length of stayOxygen saturationQALYsRemdesivir

Identifiers

PMID34379304
PMCPMC8355577
OpenAlexW3191011055

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.