Evidence map›Paper›PMID 34379175›Full record

ReviewSeminars in immunopathology2021

Complement activation in IgA nephropathy.

Nicholas R Medjeral-Thomas, H Terence Cook, Matthew C Pickering

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in immunopathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06454110 (A Phase II, Open-Label Study of NM8074 in Patients With Immunoglobulin A Nephropathy), which is not on this map. Cited by 80 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 5 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06454110 phase2not yet recruitingnot on this mapstarted 2028, after this paper: background citation

A Phase II, Open-Label Study of NM8074 in Patients With Immunoglobulin A Nephropathy (IgAN)

TypeinterventionalSponsorNovelMed TherapeuticsRan2028 to 2031Enrolled10ConditionsIgA NephropathyArmsNM8074
3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 5 syntheses or guidelines pooled it, 111 citations in OpenAlex.

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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nicholas R Medjeral-ThomasCentre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, W12 0NN, UK. n.medjeral-thomas@imperial.ac.uk.ORCID 0000-0003-4593-9487
H Terence CookCentre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, W12 0NN, UK.
Matthew C PickeringCentre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, W12 0NN, UK.
Imperial College London · GB

Funding

Wellcome Trust 212252/Z/18/Z
6 · The paper itself

Abstract

IgA nephropathy pathogenesis is incompletely understood, and this limits the development of disease-specific biomarkers and effective therapies. Evidence of complement activity in IgA nephropathy is well established. However, a growing body of research indicates complement activity is an important contributor to IgA nephropathy pathology. In particular, multiple associations have been identified between complement alternative, lectin and terminal pathway proteins and IgA nephropathy severity. Recently, we have also gained insight into possible mechanisms that could link glomerular IgA deposition, complement activity, glomerular inflammation and disease severity. Ongoing clinical trials of therapeutic complement inhibitors will provide insight into the importance of complement activity to IgA nephropathy pathogenesis. Further research into mechanisms of complement activity is essential to improving our understanding and management of patients with IgA nephropathy.

Indexed as

Glomerulonephritis, IGAComplement ActivationComplement System ProteinsHumansImmunoglobulin AKidney GlomerulusComplement System ProteinsImmunoglobulin AComplementIgA nephropathyImmunologyPathology

Identifiers

PMID34379175
PMCPMC8551128
OpenAlexW3192674683

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.