Evidence map›Paper›PMID 34379117›Full record

ArticleJournal of Crohn's & colitis2022

The Phenotypic Spectrum of New-onset IBD in Canadian Children of South Asian Ethnicity: A Prospective Multi-Centre Comparative Study.

J Dhaliwal, M W Carroll, J C deBruyn, A Ricciuto, E I Benchimol, S Lawrence, M Sherlock, W El-Matary, H Brill, P Church and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Crohn's & colitis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Inflammatory bowel disease in south Asia: a scoping review.The lancet. Gastroenterology & hepatology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 2 countries.

J DhaliwalSickKids Hospital, University of Toronto, Toronto, ON, Canada.
M W CarrollStollery Children's Hospital, University of Alberta, Edmonton, AB, Canada.
J C deBruynAlberta Children's Hospital, University of Calgary, Calgary, AB, Canada.
A RicciutoSickKids Hospital, University of Toronto, Toronto, ON, Canada.
E I BenchimolSickKids Hospital, University of Toronto, Toronto, ON, Canada.ORCID 0000-0001-8855-3598
S LawrenceBritish Columbia Children's Hospital, University of British Columbia, Vancouver, BC, Canada.
M SherlockMcMaster Children's Hospital, McMaster University, Hamilton, ON, Canada.
W El-MataryMax Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.ORCID 0000-0001-6417-7583
H BrillMcMaster Children's Hospital, McMaster University, Hamilton, ON, Canada.
P ChurchSickKids Hospital, University of Toronto, Toronto, ON, Canada.
E WineStollery Children's Hospital, University of Alberta, Edmonton, AB, Canada.
N CarmanChildren's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada.
A MuiseSickKids Hospital, University of Toronto, Toronto, ON, Canada.
H HuynhStollery Children's Hospital, University of Alberta, Edmonton, AB, Canada.
D R MackChildren's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada.
T D WaltersSickKids Hospital, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-4184-4600
A M GriffithsSickKids Hospital, University of Toronto, Toronto, ON, Canada.
K JacobsonBritish Columbia Children's Hospital, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0001-7269-8557
University of Toronto · CAUniversity of Alberta · CAUniversity of British Columbia · CAUniversity of Ottawa · CACincinnati Children's Hospital Medical Center · USMcMaster Children's Hospital · CAUniversity of Calgary · CAUniversity of Manitoba · CA

Funding

CIHR 297862
6 · The paper itself

Abstract

backgroundCanadian-born children of South Asian [SA] ethnicity develop inflammatory bowel disease [IBD] at similar rates to those among Caucasian children. We evaluated the variation in phenotypic spectrum of IBD in SA and Caucasian children in a national paediatric inception cohort of new-onset IBD.

methodsPatients aged <17 years, enrolled in a Canadian nationwide inception cohort study, were included. Baseline demographic and IBD phenotypic features were compared between SA and Caucasian children. Longitudinal outcomes through 18 months of follow-up were compared matched by propensity scores.

resultsOf 1156 children enrolled over 2014 to 2019, 623 were Caucasian [98% and 88% parents Canadian born] and 114 SA [79% Canadian born, 87% parents SA born]. Fewer SAs have a first-degree relative with IBD, 6% vs 19% in Caucasians, p = 0.002. SAs present at a younger age, median age 11.4 years (interquartile range [IQR] 9.2-14.3) vs 13 years [IQR 10.9-15 years], p = 0.03 and more commonly with a UC/IBD-U [ulcerative colitis/IBD-unclassified] subtype [ratio of UC/IBD-U to CD 1.2:1 vs 1:1.8 for Caucasians, p <0.001]. Additionally, a greater proportion of SA CD patients present with colonic-only disease [colonic-only CD/UC/IBD-U in SAs 67% vs 57% for Caucasians, p = 0.001], and among those with CD, colonic CD in SAs 31% vs 23% in Caucasians, p = 0.20]. Perianal fistulising disease was also numerically more common in SAs (14 [27%] vs 64 [18%], p = 0.06]. Adjusting for differences in phenotypic presentation, anti-tumour necrosis factor [TNF] exposure, and time to initiation was similar, and two-thirds of children, whether anti-TNF exposed or naïve, were in corticosteroid-free clinical remission at 18 months irrespective of ethnicity.

conclusionsThe phenotypic spectrum of new-onset IBD in SA children differs from that of Caucasian children, but treatment and clinical course are similar within phenotypic subgroups.

Indexed as

Colitis, UlcerativeCrohn DiseaseInflammatory Bowel DiseasesAdolescentCanadaChildCohort StudiesEthnicityHumansProspective StudiesTumor Necrosis Factor InhibitorsTumor Necrosis Factor InhibitorsCrohn’s diseaseInflammatory bowel diseasepaediatricphenotypeSouth Asianulcerative colitis

Identifiers

PMID34379117
PMCPMC8864632
OpenAlexW3187373257

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.