Evidence map›Paper›PMID 34378993›Full record

ArticleApplied and environmental microbiology2021

TroR Negatively Regulates the TroABCD System and Is Required for Resistance to Metal Toxicity and Virulence in Streptococcus suis.

Chengkun Zheng, Man Wei, Jun Qiu, Mengdie Jia, Xiaohui Zhou, Xinan Jiao

Open access · greenAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 32 citations in OpenAlex.

  1. SloR-SRE binding to theJournal of bacteriology · 2025
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  5. Mutations inApplied and environmental microbiology · 2023
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  6. The DmeRF System Is Involved in Maintaining Cobalt Homeostasis inInternational journal of molecular sciences · 2022
    Article
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Chengkun ZhengJoint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou Universitygrid.268415.c, Yangzhou, China.
Man WeiJoint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou Universitygrid.268415.c, Yangzhou, China.
Jun QiuJoint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou Universitygrid.268415.c, Yangzhou, China.
Mengdie JiaJoint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou Universitygrid.268415.c, Yangzhou, China.
Xiaohui ZhouDepartment of Pathobiology and Veterinary Science, University of Connecticutgrid.63054.34, Storrs, Connecticut, USA.ORCID 0000-0003-3205-4743
Xinan JiaoJoint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou Universitygrid.268415.c, Yangzhou, China.
Yangzhou University · CNUniversity of Connecticut · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Streptococcus suis is an emerging zoonotic pathogen that causes severe swine and human infections. Metals are essential nutrients for life; however, excess metals are toxic to bacteria. Therefore, maintenance of intracellular metal homeostasis is important for bacterial survival. Here, we characterize a DtxR family metalloregulator, TroR, in S. suis. TroR is located upstream of the

Indexed as

AnimalsATP-Binding Cassette TransportersBacterial ProteinsDrug ResistanceFemaleGene Expression Regulation, BacterialMetals, HeavyMiceMice, Inbred BALB COperonPeriplasmic Binding ProteinsRepressor ProteinsStreptococcal InfectionsStreptococcus suisVirulenceATP-Binding Cassette TransportersBacterial ProteinsMetals, HeavyPeriplasmic Binding ProteinsRepressor Proteinsmetal toxicityrepressionStreptococcus suisTroABCDTroRvirulence

Identifiers

PMID34378993
PMCPMC8478451
OpenAlexW3192736878

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.