Evidence map›Paper›PMID 34378964›Full record

ArticleMicrobiology spectrum2021

Identification of the Biosynthetic Gene Cluster for the Organoarsenical Antibiotic Arsinothricin.

Adriana E Galván, Ngozi P Paul, Jian Chen, Kunie Yoshinaga-Sakurai, Sagar M Utturkar, Barry P Rosen, Masafumi Yoshinaga

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 33 citations in OpenAlex.

  1. Synergistic function of ars genes in arsenic detoxification and biosynthesis of organoarsenicals.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Bifunctional protein ArsRBMC microbiology · 2023
    Article
  7. Arsinothricin InhibitsMicroorganisms · 2023
    Article
  8. Article
  9. Arsenic in medicine: past, present and future.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023
    Review
  10. Characterization of Two Highly Arsenic-Resistant Caulobacteraceae Strains ofInternational journal of molecular sciences · 2022
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Adriana E GalvánDepartment of Cellular Biology and Pharmacology, Florida International Universitygrid.65456.34, Herbert Wertheim College of Medicine, Miami, Florida, USA.ORCID 0000-0002-2472-0438
Ngozi P PaulDepartment of Cellular Biology and Pharmacology, Florida International Universitygrid.65456.34, Herbert Wertheim College of Medicine, Miami, Florida, USA.ORCID 0000-0003-0423-195X
Jian ChenDepartment of Cellular Biology and Pharmacology, Florida International Universitygrid.65456.34, Herbert Wertheim College of Medicine, Miami, Florida, USA.
Kunie Yoshinaga-SakuraiDepartment of Cellular Biology and Pharmacology, Florida International Universitygrid.65456.34, Herbert Wertheim College of Medicine, Miami, Florida, USA.
Sagar M UtturkarPurdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana, USA.
Barry P RosenDepartment of Cellular Biology and Pharmacology, Florida International Universitygrid.65456.34, Herbert Wertheim College of Medicine, Miami, Florida, USA.ORCID 0000-0002-5230-4271
Masafumi YoshinagaDepartment of Cellular Biology and Pharmacology, Florida International Universitygrid.65456.34, Herbert Wertheim College of Medicine, Miami, Florida, USA.ORCID 0000-0002-7243-1761
Florida International University · USPurdue University West Lafayette · US

Funding

Mechanisms of Arsenic Transport and BiotransformationsR01GM055425 · NIGMS · WAYNE STATE UNIVERSITY · PI ROSEN, BARRY P. · 1997 to 2019
$3.8M
MECHANISMS OF ARSENIC TRANSPORT AND BIOTRANSFORMATIONSR35GM136211 · NIGMS · FLORIDA INTERNATIONAL UNIVERSITY · PI ROSEN, BARRY P. · 2020 to 2024
$2.3M
The human arsenic methylation pathwayR01ES023779 · NIEHS · FLORIDA INTERNATIONAL UNIVERSITY · PI ROSEN, BARRY P. · 2015 to 2019
$1.6M
NIEHS NIH HHS R01 ES023779NIGMS NIH HHS R01 GM055425NIGMS NIH HHS R35 GM136211
6 · The paper itself

Abstract

The soil bacterium Burkholderia gladioli GSRB05 produces the natural compound arsinothricin [2-amino-4-(hydroxymethylarsinoyl) butanoate] (AST), which has been demonstrated to be a broad-spectrum antibiotic. To identify the genes responsible for AST biosynthesis, a draft genome sequence of

Indexed as

Anti-Bacterial AgentsArsenicalsBacterial ProteinsBurkholderia gladioliGenome, BacterialMethyltransferasesMultigene FamilyS-AdenosylmethionineAnti-Bacterial AgentsArsenicalsarsinothricinBacterial ProteinsMethyltransferasesS-Adenosylmethioninearsinothricinbiosynthetic gene clusterBurkholderia gladioli GSRB05organoarsenical antibiotic

Identifiers

PMID34378964
PMCPMC8552651
OpenAlexW3190181808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.