Evidence map›Paper›PMID 34378845›Full record

ReviewBiochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology2021

Genome sequencing guide: An introductory toolbox to whole-genome analysis methods.

Alexis N Burian, Wufan Zhao, Te-Wen Lo, Deborah M Thurtle-Schmidt

Open access · hybridAbstract readReview
In one paragraph

Review in Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Rapid On-Site Detection ofFoods (Basel, Switzerland) · 2026
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  10. Genome sequencing guide: An introductory toolbox to whole-genome analysis methods.Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alexis N BurianDepartment of Biology, Ithaca College, Ithaca, New York, USA.
Wufan ZhaoDepartment of Biology, Davidson College, Davidson, North Carolina, USA.
Te-Wen LoDepartment of Biology, Ithaca College, Ithaca, New York, USA.ORCID 0000-0002-1231-5531
Deborah M Thurtle-SchmidtDepartment of Biology, Davidson College, Davidson, North Carolina, USA.ORCID 0000-0002-9747-9585
Davidson College · USIthaca College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To fully appreciate genetics, one must understand the link between genotype (DNA sequence) and phenotype (observable characteristics). Advances in high-throughput genomic sequencing technologies and applications, so-called "-omics," have made genetic sequencing readily available across fields in biology from applications in non-traditional study organisms to precision medicine. Thus, understanding these tools is critical for any biologist, especially those early in their career. This comprehensive review discusses the chronological development of different sequencing methods, the bioinformatics steps to analyzing this data, and social and ethical issues raised by these techniques that must be discussed and evaluated, including anticipatory guides and discussion questions for active engagement in the classroom. Additionally, the Supporting Information includes a case study to apply technical and ethical concepts from the text.

Indexed as

GenomicsHigh-Throughput Nucleotide SequencingBase SequenceComputational BiologyGenomeSequence Analysis, DNAbioinformaticsethicsgenomicssequencing

Identifiers

PMID34378845
PMCPMC9291972
OpenAlexW3191938868

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.