Evidence map›Paper›PMID 34378840›Full record

ArticleNeurogastroenterology and motility2022

Gastrointestinal symptoms and healthcare utilization have increased among patients with functional gastrointestinal and motility disorders during the COVID-19 pandemic.

John Gubatan, Thomas Zikos, Estelle Spear Bishop, John Wu, Andrés Gottfried, Laren Becker, Aida Habtezion, Leila Neshatian

Open access · bronzeAbstract read
In one paragraph

Article in Neurogastroenterology and motility, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Article
  6. Review
  7. Diarrhea and Coronavirus Disease 2019 Infection.Gastroenterology clinics of North America · 2023
    Review
  8. Article
  9. COVID-19's impact on interest in gastrointestinal topics.Environmental science and pollution research international · 2022
    Article
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

John GubatanDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0001-6037-2883
Thomas ZikosDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0003-3212-2400
Estelle Spear BishopDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.
John WuDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.
Andrés GottfriedDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0002-3563-3727
Laren BeckerDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.
Aida HabtezionDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.
Leila NeshatianDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0003-4153-5012
Stanford University · US

Funding

Stanford TRANSFORM I2T ProgramR25AI147369 · NIAID · STANFORD UNIVERSITY · PI CHERTOW, GLENN MATTHEW, SINGH, UPINDER · 2019 to 2023
$1.8M
NIAID NIH HHS R25 AI147369NIDDK NIH HHS L30 DK126220
6 · The paper itself

Abstract

backgroundThe coronavirus disease 2019 (COVID-19) pandemic has led to unprecedented disruptions in healthcare. Functional gastrointestinal and motility disorders (FGIMD) are associated with significant healthcare utilization. The clinical implications of these healthcare disruptions due to the COVID-19 pandemic on clinical outcomes in patients with FGIMD are unclear.

methodsWe performed a retrospective study of patients with three common FGIMD (irritable bowel syndrome [IBS], gastroparesis, functional dyspepsia [FD]) tested for SARS-CoV-2 to describe alterations in gastrointestinal symptoms, medication use, and healthcare utilization during and before the pandemic and factors associated with COVID-19. KEY

resultsThe prevalence of COVID-19 during the pandemic (03/2020-09/2020) was 3.20% (83/2592) among patients with FGIMD, 3.62% in IBS (57/1574), 3.07% in gastroparesis (23/749), and 2.44% in FD (29/1187) at our institution. Patients with FGIMD had increased abdominal pain, nausea/vomiting, diarrhea, constipation, and weight loss (p < 0.001) along with increased proton pump inhibitor, H2 blocker, and opioid use (p < 0.0001). Both inpatient hospitalizations and outpatient visits (p < 0.0001) and number of diagnostic tests including cross-sectional imaging (p = 0.002), and upper and lower endoscopies (p < 0.0001) were significantly higher during the pandemic as compared to 6 months prior. Diarrhea-predominant IBS was positively (OR 2.37, 95% CI 1.34-4.19, p = 0.003) associated with COVID-19, whereas functional dyspepsia was negatively (OR 0.46, 95% CI 0.27-0.79, p = 0.004) associated. CONCLUSIONS & INFERENCES: Patients with common functional gastrointestinal and motility disorders have reported more gastrointestinal symptoms during the COVID-19 pandemic with concurrent increased medication use and healthcare utilization.

Indexed as

COVID-19DyspepsiaGastrointestinal DiseasesIrritable Bowel SyndromeDelivery of Health CareHumansPandemicsPatient Acceptance of Health CareRetrospective StudiesSARS-CoV-2COVID-19functional dyspepsiafunctional GI and motility disordersgastroparesishealthcare utilizationirritable bowel syndromeSARS-COV-2

Identifiers

PMID34378840
PMCPMC8420203
OpenAlexW3190330809

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.