ArticleeLife2021
Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Skin-derived G-CSF activates pathological granulopoiesis upon psoriasis.EMBO molecular medicine · 2026Article
- Tonic and early interferons defend against respiratory viruses in primary human lung organoid-derived air-liquid interface cultures.Journal of virology · 2026Article
- Mammalian innate antiviral defenses: beyond interferon.Journal of virology · 2025Review
- Aging associated immunosenescence in rheumatoid arthritis identified by machine learning and single cell profiling.Scientific reports · 2025Article
- Gastric Cancer and Microbiota: Exploring the Microbiome's Role in Carcinogenesis and Treatment Strategies.Life (Basel, Switzerland) · 2025Review
- Metabolic reprogramming tips vaccinia virus infection outcomes by stabilizing interferon-γ induced IRF1.PLoS pathogens · 2024Article
- Cell-intrinsic regulation of phagocyte function by interferon lambda during pulmonary viral, bacterial super-infection.PLoS pathogens · 2024Article
- An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection.Microbiology spectrum · 2024Article
- STAT1 Employs Myeloid Cell-Extrinsic Mechanisms to Regulate the Neutrophil Response and Provide Protection against Invasive Klebsiella pneumoniae Lung Infection.ImmunoHorizons · 2024Article
- In sickness and in health-Type I interferon and the brain.Frontiers in aging neuroscience · 2024Review
- Tonic TNF conditioning of macrophages safeguards stimulus-specific inflammatory responses.EMBO reports · 2023Article
- STAT1 Controls the Functionality of Influenza-Primed CD4 T Cells but Therapeutic STAT4 Engagement Maximizes Their Antiviral Impact.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- The Microbiota-Dependent Worsening Effects of Melatonin on Gut Inflammation.Microorganisms · 2023Article
- STAT1 deficiency underlies a proinflammatory imprint of naive CD4Frontiers in immunology · 2023Article
- T cell intrinsic STAT1 signaling prevents aberrant Th1 responses during acute toxoplasmosis.Frontiers in immunology · 2023Article
- Article
- Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation.Cell reports · 2022Article
- Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic.The Journal of experimental medicine · 2022Article
- Assessing the Presence of Hematopoietic Stem and Progenitor Cells in Mouse Spleen.Bio-protocol · 2022Article
- Multi-Omics Reveals Different Strategies in the Immune and Metabolic Systems of High-Yielding Strains of Laying Hens.Frontiers in genetics · 2022Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
Maintenance of immune homeostasis involves a synergistic relationship between the host and the microbiome. Canonical interferon (IFN) signaling controls responses to acute microbial infection, through engagement of the STAT1 transcription factor. However, the contribution of tonic levels of IFN to immune homeostasis in the absence of acute infection remains largely unexplored. We report that STAT1 KO mice spontaneously developed an inflammatory disease marked by myeloid hyperplasia and splenic accumulation of hematopoietic stem cells. Moreover, these animals developed inflammatory bowel disease. Profiling gut bacteria revealed a profound dysbiosis in the absence of tonic IFN signaling, which triggered expansion of T
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.