Evidence map›Paper›PMID 34378315›Full record

Observational studyHemodialysis international. International Symposium on Home Hemodialysis2022

End-stage kidney disease patients from ethnic minorities and mortality in coronavirus disease 2019.

Matthew Tabinor, Lisa Emma Crowley, Alexandra Godlee, Daisy Flanagan, Raja Muhammad Rashid, Jyoti Baharani, Charles Joseph Ferro, Helen Eddington

Open access · bronzeAbstract readObservational Study
In one paragraph

Observational study in Hemodialysis international. International Symposium on Home Hemodialysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. End-stage kidney disease patients from ethnic minorities and mortality in coronavirus disease 2019.Hemodialysis international. International Symposium on Home Hemodialysis · 2022
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Matthew TabinorDepartment of Renal Medicine, University Hospitals of Birmingham NHS Trust, Birmingham, UK.ORCID 0000-0003-3362-2239
Lisa Emma CrowleyDepartment of Renal Medicine, University Hospitals of Birmingham NHS Trust, Birmingham, UK.
Alexandra GodleeDepartment of Renal Medicine, University Hospitals of Birmingham NHS Trust, Birmingham, UK.
Daisy FlanaganDepartment of Renal Medicine, University Hospitals of Birmingham NHS Trust, Birmingham, UK.
Raja Muhammad RashidDepartment of Renal Medicine, University Hospitals of Birmingham NHS Trust, Birmingham, UK.
Jyoti BaharaniDepartment of Renal Medicine, University Hospitals of Birmingham NHS Trust, Birmingham, UK.ORCID 0000-0003-4539-9927
Charles Joseph FerroDepartment of Renal Medicine, University Hospitals of Birmingham NHS Trust, Birmingham, UK.ORCID 0000-0003-0577-7081
Helen EddingtonDepartment of Renal Medicine, University Hospitals of Birmingham NHS Trust, Birmingham, UK.
University Hospitals Birmingham NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCoronavirus disease 2019 (COVID-19) adversely affects patients who are older, multimorbid, and from Black, Asian or minority ethnicities (BAME). We assessed whether being from BAME is independently associated with mortality in end-stage kidney disease (ESKD) patients with COVID-19.

methodsProspective observational study in a single UK renal center. A study was conducted between March 10, 2020 and April 30, 2020. Demographics, socioeconomic deprivation (index of multiple deprivation), co-morbidities (Charlson comorbidity index [CCI]), and frailty data (clinical frailty score) were collected. The primary outcome was all-cause mortality. Data were censored on the 1st June 2020.

findingsOverall, 191 of our 3379 ESKD patients contracted COVID-19 in the 8-week observation period; 84% hemodialysis, 5% peritoneal dialysis, and 11% kidney transplant recipients (KTR). Of these, 57% were male and 67% were from BAME groups (43% Asian, 17% Black, 2% mixed race, and 5% other). Mean CCI was 7.45 (SD 2.11) and 3.90 (SD 2.10) for dialysis patients and KTR, respectively. In our cohort, 60% of patients lived in areas classified as being in the most deprived 20% in the United Kingdom, and of these, 77% of patients were from BAME groups. The case fatality rate was 29%. Multivariable cox regression demonstrated that BAME (hazard ratio [HR]: 2.37, 95% CI: 1.22-4.61) was associated with all-cause mortality after adjustment for age, deprivation, co-morbidities, and frailty. Associations with all-cause mortality persisted in sensitivity analyses in patients from South Asian (HR: 2.52, 95% CI: 1.24-5.12) and Black (HR: 2.43, 95% CI: 1.04-5.67) ethnic backgrounds. DISCUSSION: BAME ESKD patients with COVID-19 are just over twice as likely to die compared to White patients, despite adjustment for age, deprivation, comorbidity, and frailty. This study highlights the need to develop strategies to improve BAME patient outcomes in future outbreaks of COVID-19.

Indexed as

COVID-19Kidney Failure, ChronicEthnic and Racial MinoritiesHumansMaleRenal DialysisSARS-CoV-2coronavirus disease 2019end-stage kidney diseaseethnicityhealth care inequalityrenal replacement therapy

Identifiers

PMID34378315
PMCPMC8444789
OpenAlexW3191888330

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.