ArticleIndian journal of pediatrics2022
COVID-19 in Children with Cancer and Continuation of Cancer-Directed Therapy During the Infection.
Article in Indian journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Epidemiology and clinical features of SARS-CoV-2 infection in children and adolescents in the pre-Omicron era: A global systematic review and meta-analysis.Journal of global health · 2024Pooled it
- The Global Impact of COVID-19 on Childhood Cancer Outcomes and Care Delivery - A Systematic Review.Frontiers in oncology · 2022Pooled it
- Challenges in Treating Pediatric Cancer Patients during the COVID-19 Pandemic: Balancing Risks and Care.Viruses · 2024Review
- Continuing Cancer-Directed Therapy in Children with COVID-19 Infection-Adopting Newer Strategies?Indian journal of pediatrics · 2022Article
- Impact of the COVID pandemic on survivors of childhood cancer and survivorship care: lessons for the future.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Clinical Course of COVID-19 Disease in Children Treated With Neoplastic Diseases in Hungary.Pathology oncology research : POR · 2022Article
- Association of Cancer Diagnosis and Therapeutic Stage With Mortality in Pediatric Patients With COVID-19, Prospective Multicenter Cohort Study From Latin America.Frontiers in pediatrics · 2022Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo report the experience with COVID-19 in children with cancer at the largest tertiary-cancer care and referral center in India.
methodsThis study is a single tertiary center experience on COVID-19 in children with cancer and continuation of cancer-directed therapy in them. Children ≤ 15 y on active cancer treatment detected with COVID-19 until September 15
resultsOne hundred twenty-two children (median age 8 y; range 1-15 y, male:female 1.7:1) with cancer were diagnosed with COVID-19. Of 118 children, 99 (83.9%), 60 (50.8%), 43 (36.4%), 26 (22.0%), and 6 (5.1%) had RT-PCR positivity at 14, 21, 28, 35, and 60 d from diagnosis of COVID-19, respectively. Scheduled risk-directed intravenous chemotherapy was delivered in 70 (90.9%) of 77 children on active systemic treatment with a median delay of 14 d (range 0-48 d) and no increased toxicities. All-cause mortality rate was 7.4% (n = 9) and COVID-19 related mortality rate was 4.9% (n = 6). One hundred-fifteen (94.2%) children with COVID-19 did not require any form of respiratory support during the course of infection.
conclusionsCOVID-19 was not a major deterrent for the continuation of active cancer treatment despite persistent RT-PCR positivity. The long-term assessment of treatment adaptations requires further prospective follow-up and real-time addressal.
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