Evidence map›Paper›PMID 34378062›Full record

ArticleEuropean journal of pediatrics2022

Neurological involvement in children with hemolytic uremic syndrome.

Caoimhe Costigan, Tara Raftery, Anne G Carroll, Dermot Wildes, Claire Reynolds, Robert Cunney, Niamh Dolan, Richard J Drew, Bryan J Lynch, Declan J O'Rourke and 8 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Observational
  5. Observational
  6. Article
  7. Article
  8. Long-term outcome and management of complement-mediated thrombotic microangiopathy/aHUS.Hematology. American Society of Hematology. Education Program · 2025
    Review
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  10. Article
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  17. Article
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  19. Article
  20. EnterohemorrhagicInternational journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Caoimhe Costigan *Department of Nephrology, Children's Health Ireland At Temple Street and Crumlin, Dublin, Ireland.
Tara Raftery *Department of Nephrology, Children's Health Ireland At Temple Street and Crumlin, Dublin, Ireland.
Anne G CarrollDepartment of Radiology, Children's Health Ireland At Temple Street, Dublin, Ireland.
Dermot WildesDepartment of Nephrology, Children's Health Ireland At Temple Street and Crumlin, Dublin, Ireland.
Claire ReynoldsDepartment of Nephrology, Children's Health Ireland At Temple Street and Crumlin, Dublin, Ireland.
Robert CunneyDepartment of Clinical Microbiology, Children's Health Ireland At Temple Street, Dublin, Ireland.
Niamh DolanDepartment of Nephrology, Children's Health Ireland At Temple Street and Crumlin, Dublin, Ireland.
Richard J DrewDepartment of Clinical Microbiology, Children's Health Ireland At Temple Street, Dublin, Ireland.
Bryan J LynchDepartment of Neurology and Clinical Neurophysiology, Children's Health Ireland At Temple Street, Dublin, Ireland.
Declan J O'RourkeDepartment of Neurology and Clinical Neurophysiology, Children's Health Ireland At Temple Street, Dublin, Ireland.
Maria StackDepartment of Nephrology, Children's Health Ireland At Temple Street and Crumlin, Dublin, Ireland.
Clodagh SweeneyDepartment of Nephrology, Children's Health Ireland At Temple Street and Crumlin, Dublin, Ireland.
Amre ShahwanDepartment of Neurology and Clinical Neurophysiology, Children's Health Ireland At Temple Street, Dublin, Ireland.
Eilish TwomeyDepartment of Radiology, Children's Health Ireland At Temple Street, Dublin, Ireland.
Mary WaldronDepartment of Nephrology, Children's Health Ireland At Temple Street and Crumlin, Dublin, Ireland.
Michael RiordanDepartment of Nephrology, Children's Health Ireland At Temple Street and Crumlin, Dublin, Ireland.
Atif Awan *Department of Nephrology, Children's Health Ireland At Temple Street and Crumlin, Dublin, Ireland.
Kathleen M Gorman *Department of Neurology and Clinical Neurophysiology, Children's Health Ireland At Temple Street, Dublin, Ireland. Kathleen.gorman1@ucd.ie.
Children's Health Ireland at Crumlin · IERoyal College of Surgeons in Ireland · IERotunda Hospital · IEUniversity College Dublin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our objective was to establish the rate of neurological involvement in Shiga toxin-producing Escherichia coli-hemolytic uremic syndrome (STEC-HUS) and describe the clinical presentation, management and outcome. A retrospective chart review of children aged ≤ 16 years with STEC-HUS in Children's Health Ireland from 2005 to 2018 was conducted. Laboratory confirmation of STEC infection was required for inclusion. Neurological involvement was defined as encephalopathy, focal neurological deficit, and/or seizure activity. Data on clinical presentation, management, and outcome were collected. We identified 240 children with HUS; 202 had confirmed STEC infection. Neurological involvement occurred in 22 (11%). The most common presentation was seizures (73%). In the neurological group, 19 (86%) were treated with plasma exchange and/or eculizumab. Of the 21 surviving children with neurological involvement, 19 (91%) achieved a complete neurological recovery. A higher proportion of children in the neurological group had renal sequelae (27% vs. 12%, P = .031). One patient died from multi-organ failure.Conclusion: We have identified the rate of neurological involvement in a large cohort of children with STEC-HUS as 11%. Neurological involvement in STEC-HUS is associated with good long-term outcome (complete neurological recovery in 91%) and a low case-fatality rate (4.5%) in our cohort. What is Known: • HUS is associated with neurological involvement in up to 30% of cases. • Neurological involvement has been reported as predictor of poor outcome, with associated increased morbidity and mortality. What is New: • The incidence of neurological involvement in STEC-HUS is 11%. • Neurological involvement is associated with predominantly good long-term outcome (90%) and a reduced case-fatality rate (4.5%) compared to older reports.

Indexed as

Escherichia coli InfectionsHemolytic-Uremic SyndromeShiga-Toxigenic Escherichia coliAdolescentChildHumansPlasma ExchangeRetrospective StudiesHUSNeurological involvementNeurologySTEC-HUS

Identifiers

PMID34378062
PMCPMC8821508
OpenAlexW3167619287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.