SynthesisDiseases of the esophagus : official journal of the International Society for Diseases of the Esophagus2021
Long-term neurodevelopment in children born with esophageal atresia: a systematic review.
Synthesis in Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The International Network on Oesophageal Atresia (INoEA) consensus guidelines on the transition of patients with oesophageal atresia-tracheoesophageal fistula.Nature reviews. Gastroenterology & hepatology · 2023Guideline
- Systematic review of long term follow-up and transitional care in adolescents and adults with esophageal atresia - why is transitional care mandatory?European journal of pediatrics · 2023Pooled it
- Perioperative monitoring in oesophageal atresia and congenital diaphragmatic hernia patients - exploring the impact of diagnosis on neurocardiovascular coupling.Journal of clinical monitoring and computing · 2026Article
- Neurodevelopmental assessment at 24 months in infants with esophageal atresia: A prospective cohort study.Journal of pediatric gastroenterology and nutrition · 2026Article
- Parents' experiences of condition management in children born with esophageal atresia-tracheoesophageal fistula during their early childhood.Orphanet journal of rare diseases · 2026Article
- Esophageal Atresia: From worry to wisdom-Global pediatrics · 2025Article
- Longitudinal Analysis of Growth and Neurodevelopmental Outcomes in Very Low Birth Weight Infants With Congenital Anomalies Over Three Years.Journal of Korean medical science · 2025Article
- Complex trajectories are associated with neurological impairment in infants with congenital gastrointestinal malformations aged two.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Retrospective analysis of early neurodevelopmental outcomes after esophageal atresia repair at a single institution:Frontiers in pediatrics · 2025Article
- The risk of autism spectrum disorder and intellectual disability but not attention deficit/hyperactivity disorder is increased in individuals with esophageal atresia.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2023Article
- Clinical outcome, quality of life, and mental health in long-gap esophageal atresia: comparison of gastric sleeve pull-up and delayed primary anastomosis.Pediatric surgery international · 2023Article
- Infant Perioperative Risk Factors and Adverse Brain Findings Following Long-Gap Esophageal Atresia Repair.Journal of clinical medicine · 2023Article
- Neurodevelopmental outcomes in individuals with VACTERL association. A population-based cohort study.PloS one · 2023Article
- Utility of Functional Lumen Imaging Probe in Long-Term Follow-Up of Children with Esophageal Atresia: A Single-Center Retrospective Study.Children (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the survival rate of esophageal atresia (EA) has increased to over 90%, the risk of functional long-term neurodevelopmental deficits is uncertain. Studies on long-term outcomes of children with EA show conflicting results. Therefore, we provide an overview of the current knowledge on the long-term neurodevelopmental outcome of children with EA.
methodsWe performed a structured literature search in Embase, Medline Ovid, Web of Science, Cochrane CENTRAL, and Google scholar on November 8, 2020 with the keywords 'esophageal atresia', 'long-term outcome', 'motor development', 'cognitive development', and 'neurodevelopment'.
resultsThe initial search identified 945 studies, of which 15 were included. Five of these published outcomes of multiple tests or tested at multiple ages. Regarding infants, one of six studies found impaired neurodevelopment at 1 year of age. Regarding preschoolers, two of five studies found impaired neurodevelopment; the one study assessing cognitive development found normal cognitive outcome. Both studies on motor function reported impairment. Regarding school-agers, the one study on neurodevelopmental outcome reported impairment. Cognitive impairment was found in two out of four studies, and motor function was impaired in both studies studying motor function.
conclusionsLong-term neurodevelopment of children born with EA has been assessed with various instruments, with contrasting results. Impairments were mostly found in motor function, but also in cognitive performance. Generally, the long-term outcome of these children is reason for concern. Structured, multidisciplinary long-term follow-up programs for children born with EA would allow to timely detect neurodevelopmental impairments and to intervene, if necessary.
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Registered trials
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