ArticleCerebral cortex communications2021
Mechanism Exploration of 3-Hinge Gyral Formation and Pattern Recognition.
Article in Cerebral cortex communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Mechanics of the Spatiotemporal Evolution of Sulcal Pits in the Folding Brain.Human brain mapping · 2025Article
- Mechanical characterization of brain tissue: experimental techniques, human testing considerations, and perspectives.Acta biomaterialia · 2025Review
- Article
- Article
- Mechanical hierarchy in the formation and modulation of cortical folding patterns.Scientific reports · 2023Article
- An integrated finite element method and machine learning algorithm for brain morphology prediction.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Identification for the cortical 3-Hinges folding pattern based on cortical morphological and structural features.Frontiers in neuroscience · 2023Article
- Cortical thickness systematically varies with curvature and depth in healthy human brains.Human brain mapping · 2022Article
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Authors and funding
3 authors.
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Abstract
The 3-hinge gyral folding is the conjunction of gyrus crest lines from three different orientations. Previous studies have not explored the possible mechanisms of formation of such 3-hinge gyri, which are preserved across species in primate brains. We develop a biomechanical model to mimic the formation of 3-hinge patterns on a real brain and determine how special types of 3-hinge patterns form in certain areas of the model. Our computational and experimental imaging results show that most tertiary convolutions and exact locations of 3-hinge patterns after growth and folding are unpredictable, but they help explain the consistency of locations and patterns of certain 3-hinge patterns. Growing fibers within the white matter is posited as a determining factor to affect the location and shape of these 3-hinge patterns. Even if the growing fibers do not exert strong enough forces to guide gyrification directly, they still may seed a heterogeneous growth profile that leads to the formation of 3-hinge patterns in specific locations. A minor difference in initial morphology between two growing model brains can lead to distinct numbers and locations of 3-hinge patterns after folding.
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