Evidence map›Paper›PMID 34377967›Full record

ArticleEClinicalMedicine2021

Electrocardiographic manifestations of COVID-19: Effect on cardiac activation and repolarization.

Avni Thakore, James Nguyen, Simcha Pollack, Stefan Muehlbauer, Benjamin Chi, Derek Knight, Bhoomi Mehrotra, Joshua Stern, J Jane Cao, Charles Lucore and 1 more

Open access · goldAbstract read
In one paragraph

Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Are Pre-Hospitalization ECG Abnormalities Associated With Increased Mortality in COVID-19 Patients? A Quantitative Systematic Literature Review.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2024
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Prospective electrocardiographic and cardiovascular magnetic resonance alterations in the UK Biobank coronavirus disease 2019 repeat imaging study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
    Article
  6. Observational
  7. Review
  8. Article
  9. Effects of COVID-19 on Arrhythmia.Journal of cardiovascular development and disease · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Avni ThakoreDepartment of Cardiology and Research, St. Francis Hospital, The Heart Center - 100 Port Washington Blvd, Roslyn, New York 11576, United States.
James NguyenDepartment of Cardiology and Research, St. Francis Hospital, The Heart Center - 100 Port Washington Blvd, Roslyn, New York 11576, United States.
Simcha PollackDepartment of Cardiology and Research, St. Francis Hospital, The Heart Center - 100 Port Washington Blvd, Roslyn, New York 11576, United States.
Stefan MuehlbauerDepartment of Emergency Medicine, St. Francis Hospital, The Heart Center -100 Port Washington Blvd, Roslyn, New York 11576, United States.
Benjamin ChiDepartment of Cardiology and Research, St. Francis Hospital, The Heart Center - 100 Port Washington Blvd, Roslyn, New York 11576, United States.
Derek KnightDepartment of Cardiology and Research, St. Francis Hospital, The Heart Center - 100 Port Washington Blvd, Roslyn, New York 11576, United States.
Bhoomi MehrotraDepartment of Hematology and Oncology, St. Francis Hospital, The Heart Center - 100 Port Washington Blvd, Roslyn , New York 11576, United States.
Joshua SternDepartment of Cardiology and Research, St. Francis Hospital, The Heart Center - 100 Port Washington Blvd, Roslyn, New York 11576, United States.
J Jane CaoDepartment of Cardiology and Research, St. Francis Hospital, The Heart Center - 100 Port Washington Blvd, Roslyn, New York 11576, United States.
Charles LucoreDepartment of Cardiology and Research, St. Francis Hospital, The Heart Center - 100 Port Washington Blvd, Roslyn, New York 11576, United States.
Joseph LevineDepartment of Cardiology and Research, St. Francis Hospital, The Heart Center - 100 Port Washington Blvd, Roslyn, New York 11576, United States.
St. Francis Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProlonged QT intervals are reported in patients with COVID-19. Additionally, virus particles in heart tissue and abnormal troponin levels have been reported. Consequently, we hypothesize that cardiac electrophysiologic abnormalities may be associated with COVID-19.

methodsThis is a retrospective study between March 15

findingsBaseline QTc of inpatients was prolonged compared to patients discharged (450.1±30.2 versus 423.4±21.7  msec,

interpretationQRS and QTc intervals are early markers for COVID-19 disease progression and mortality. ECG, a readily accessible tool, identifies cardiac involvement and may be used to predict disease course.

fundingSt. Francis Foundation.

Indexed as

ActivationBNPCardiac involvementCOVID-19ElectrocardiogramMortalityNTPRO BNPQRSQTc intervalQT intervalrepolarizationSAR-COV-2Troponin

Identifiers

PMID34377967
PMCPMC8343356
OpenAlexW3191647079

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.