Evidence map›Paper›PMID 34377934›Full record

Trial reportJNCI cancer spectrum2021

Alexander H G Paterson, Peter C Lucas, Stewart J Anderson, Eleftherios P Mamounas, Adam Brufsky, Luis Baez-Diaz, Karen M King, Thomas Lad, André Robidoux, Melanie Finnigan and 7 more

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in JNCI cancer spectrum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. SEOM-GEICAM-SOLTI clinical guidelines for early-stage breast cancer (UPDATE 2025).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Guideline
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 3 countries.

Alexander H G PatersonNSABP Foundation and NRG Oncology, Pittsburgh, PA, USA.ORCID 0000-0002-3138-3337
Peter C LucasNSABP Foundation and NRG Oncology, Pittsburgh, PA, USA.ORCID 0000-0003-4880-7172
Stewart J AndersonNSABP Foundation and NRG Oncology, Pittsburgh, PA, USA.ORCID 0000-0001-8948-0650
Eleftherios P MamounasNSABP Foundation and NRG Oncology, Pittsburgh, PA, USA.
Adam BrufskyNSABP Foundation and NRG Oncology, Pittsburgh, PA, USA.ORCID 0000-0001-8080-7960
Luis Baez-DiazNSABP Foundation and NRG Oncology, Pittsburgh, PA, USA.
Karen M KingNSABP Foundation and NRG Oncology, Pittsburgh, PA, USA.
Thomas LadNSABP Foundation and NRG Oncology, Pittsburgh, PA, USA.ORCID 0000-0002-9258-5522
André RobidouxNSABP Foundation and NRG Oncology, Pittsburgh, PA, USA.
Melanie FinniganNSABP Foundation and NRG Oncology, Pittsburgh, PA, USA.
Miguel SampayoSyntax for Science SL, Palma de Mallorca, Spain.ORCID 0000-0003-1469-3410
Juan Carlos TerceroInbiomotion SL, Barcelona, Spain.
Joël Jean MairetInbiomotion SL, Barcelona, Spain.
Antonio C WolffNSABP Foundation and NRG Oncology, Pittsburgh, PA, USA.ORCID 0000-0003-3734-1063
Louis FehrenbacherNSABP Foundation and NRG Oncology, Pittsburgh, PA, USA.
Norman WolmarkNSABP Foundation and NRG Oncology, Pittsburgh, PA, USA.
Roger R GomisCancer Science, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID 0000-0001-6473-2858
NRG Oncology · USUniversity of Pittsburgh · USCentre Hospitalier de l’Université de Montréal · CAInstitució Catalana de Recerca i Estudis Avançats · ESJohn H. Stroger, Jr. Hospital of Cook County · USKaiser Permanente Vallejo Medical Center · USOrlando Health · USUniversity of Calgary · CA

Funding

NRG Oncology Network Group Operations Center - GY9 BIQSFP Reports/BudgetsU10CA180868 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI NORMAN WOLMARK · 2014 to 2026
$206.8M
Statistics CoreU10CA180822 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI James J. Dignam, GREG YOTHERS · 2014 to 2026
$146.4M
NRG Oncology NCORP Research Base-BIQSFPUG1CA189867 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI Deborah Watkins Bruner, Lisa A. Kachnic · 2014 to 2026
$140.5M
NRG Oncology Biospecimen BankU24CA196067 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI Tanner J. Freeman, Nilsa Del Carmen Ramirez Milan · 2015 to 2026
$42.6M
NCI NIH HHS U10 CA180822NCI NIH HHS U10 CA180868NCI NIH HHS U24 CA196067NCI NIH HHS UG1 CA189867
6 · The paper itself

Abstract

Background: The Adjuvant Zoledronic Acid (ZA) study in early breast cancer (AZURE) showed correlation between a nonamplified Methods: A retrospective analysis of Results: Conclusions: Nonamplified

Indexed as

Gene AmplificationAdministration, OralBone Density Conservation AgentsBreast NeoplasmsChemotherapy, AdjuvantClodronic AcidConfidence IntervalsDisease-Free SurvivalDouble-Blind MethodFemaleHumansInjections, IntravenousIn Situ Hybridization, FluorescenceMiddle AgedPlacebosProto-Oncogene Proteins c-mafBone Density Conservation AgentsClodronic AcidMAF protein, humanPlacebosProto-Oncogene Proteins c-mafZoledronic Acid

Identifiers

PMID34377934
PMCPMC8346694
OpenAlexW3168792227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.