ArticleClinical neurophysiology practice2021
Reduction in median nerve cross-sectional area at the forearm correlates with axon loss in carpal tunnel syndrome.
Article in Clinical neurophysiology practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Ultrasound-Based Severity Stratification in Carpal Tunnel Syndrome: Median Nerve Cross-Sectional Area for Distinguishing Severe from Moderate Disease.Diagnostics (Basel, Switzerland) · 2026Article
- Ultrasound Cross-Sectional Area in Median Nerve Axonal Loss and Demyelination in Carpal Tunnel Syndrome.Journal of hand and microsurgery · 2024Article
- Median nerve ultrasound cross sectional area and wrist-to-forearm ratio in relation to carpal tunnel syndrome related axonal damage and patient age.Clinical neurophysiology practice · 2023Article
- Evaluation of the Existing Electrophysiological Severity Classifications in Carpal Tunnel Syndrome.Journal of clinical medicine · 2022Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the relationship between axon loss and measured cross-sectional areas of the median nerve (MN) in severe carpal tunnel syndrome (CTS).
methodsIn this retrospective study of 158 examined wrists, we compared axon loss to the ultrasound parameters MN cross-sectional area at the wrist (wCSA), MN cross-sectional area at the forearm (fCSA) and wrist-to-forearm ratio (WFR), in patients with moderate to extreme CTS. Axon loss was evaluated by needle electromyography (EMG) of the abductor pollicis brevis muscle (spontaneous activity and reduction of interference pattern).
resultsBoth the spontaneous activity and interference pattern reduction correlated negatively to fCSA (r = -0.189, p = 0.035; r = -0.210, p = 0.019; respectively). In moderate CTS, both the spontaneous activity and interference pattern reduction correlated positively to WFR (r = 0.231, p = 0.048; r = 0.232, p = 0.047; respectively). The WFR was highest when slight spontaneous activity was detected. Neither wCSA nor WFR correlated with axon loss in severe and extreme CTS.
conclusionsThe fCSA is smaller when axon loss in CTS is more prominent. The WFR is highest when CTS is associated with slight axon loss of the MN. SIGNIFICANCE: CTS might cause retrograde axonal atrophy detected as small fCSA. Prominent axon loss in CTS may reduce the diagnostic value of WFR.
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