ArticleMolecular therapy. Methods & clinical development2021
Evidence generation and reproducibility in cell and gene therapy research: A call to action.
Abstract readEditorial
In one paragraph
Article in Molecular therapy. Methods & clinical development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- A tumor-on-a-chip for in vitro study of CAR-T cell immunotherapy in solid tumors.Nature biotechnology · 2026Article
- Adoptive T-cell therapies in the clinic.Bioengineering & translational medicine · 2026Review
- Designs of the clinical trials aiming at evaluating cell and gene therapy products: A critical appraisal from a literature review.Molecular therapy. Advances · 2026Review
- Bioengineering breakthroughs: The impact of stem cell models on advanced therapy medicinal product development.World journal of stem cells · 2024Review
- Biomanufacturing in gene and cell therapy.Molecular therapy. Methods & clinical development · 2024Article
- From precision medicine to precision care: Choosing and using precision medicine in the context of multimorbidity.Cambridge prisms. Precision medicine · 2023Review
- Applying a clinical lens to animal models of CAR-T cell therapies.Molecular therapy. Methods & clinical development · 2022Review
- Stain-Free total-protein normalization enhances the reproducibility of Western blot data.Analytical biochemistry · 2022Article
- Improved MSC Minimal Criteria to Maximize Patient Safety: A Call to Embrace Tissue Factor and Hemocompatibility Assessment of MSC Products.Stem cells translational medicine · 2022Article
- Mass Customized Outlook for Regenerative Heart Failure Care.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors.
Mohamed Abou-El-EneinDivision of Medical Oncology, Department of Medicine and Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Aris AngelisDepartment of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK.
Frederick R AppelbaumClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Nancy C AndrewsDepartment of Pharmacology and Cancer Biology and Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.
Susan E BatesDepartment of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.
Arlene S BiermanCenter for Evidence and Practice Improvement, Agency for Healthcare Research and Quality, Rockville, MD, USA.
Malcolm K BrennerCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Marina CavazzanaBiotherapy Department, Necker Children's Hospital, Assistance Publique-Hopitaux de Paris, Paris, France.
Michael A CaligiuriHematologic Malignancies and Stem Cell Transplantation Institute, City of Hope National Medical Center, Duarte, CA, USA.
Hans CleversHubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, the Netherlands.
Emer CookeEuropean Medicines Agency, Amsterdam, the Netherlands.
George Q DaleyBoston Children's Hospital, Boston, MA, USA.
Victor J DzauUS National Academy of Medicine, Washington, DC, USA.
Lee M EllisDepartment of Surgical Oncology and Molecular & Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Harvey V FinebergGordon and Betty Moore Foundation, Palo Alto, CA, USA.
Lawrence S B GoldsteinDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Stephen GottschalkDepartment of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA.
Margaret A HamburgAmerican Association for the Advancement of Science (AAAS), Washington, DC, USA.
Donald E IngberBoston Children's Hospital, Boston, MA, USA.
Donald B KohnDepartment of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Adrian R KrainerCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Marcela V MausHarvard Medical School, Boston, MA, USA.
Peter MarksCenter for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.
Christine L MummeryDepartment of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands.
Roderic I PettigrewENMED, Colleges of Medicine and Engineering, Texas A&M University, Houston, TX, USA.
Joni L RutterNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.
Sarah A TeichmannWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
Andre TerzicCenter for Regenerative Medicine, Mayo Clinic, Rochester, MN, USA.
Fyodor D UrnovInnovative Genomics Institute, University of California, Berkeley, CA, USA.
David A WilliamsBoston Children's Hospital, Boston, MA, USA.
Jedd D WolchokHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mark LawlerPatrick G Johnston Centre for Cancer Research, Faculty of Medicine, Health and Life Sciences, Queen's University Belfast, Belfast, UK.
Cameron J TurtleClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Gerhard BauerInstitute for Regenerative Cures, University of California, Davis, Sacramento, CA, USA.
John P A IoannidisStanford Prevention Research Center, Department of Medicine, Stanford University, Stanford, CA, USA.
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MVIRAL TRANSACTIVATIONP01CA013106 · NCI · COLD SPRING HARBOR LABORATORY · PI Camila dos Santos · 1985 to 2026
$116.8MBIOCHEMISTRY OF PREMRNA SPLICINGR01GM042699 · NIGMS · COLD SPRING HARBOR LABORATORY · PI Adrian R Krainer · 1989 to 2026
$8.8MHuman natural killer cells: Advancing biology and clinical applicationsR35CA210087 · NCI · OHIO STATE UNIVERSITY · PI MICHAEL A CALIGIURI · 2017 to 2026
$8.3MBiochemistry of Pre-mRNA SplicingR37GM042699 · NIGMS · COLD SPRING HARBOR LABORATORY · PI KRAINER, ADRIAN R · 2012 to 2021
$7.7MIMMUNIZATION AGAINST MELANOMA DIFFERENTIATION ANTIGENSR01CA056821 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI WOLCHOK, JEDD D. · 1992 to 2020
$5.7MENHANCING CARDIOPOIETIC REGENERATION FOR ISCHEMIC CARDIOMYOPATHYR01HL134664 · NHLBI · MAYO CLINIC ROCHESTER · PI TERZIC, ANDRE · 2018 to 2021
$1.6MNCI NIH HHS P01 CA013106NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA056821NCI NIH HHS R35 CA210087NHLBI NIH HHS R01 HL134664NIGMS NIH HHS R01 GM042699NIGMS NIH HHS R37 GM042699
Abstract
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.