Evidence map›Paper›PMID 34377680›Full record

ArticleToxicology reports2021

Determination of benchmark doses for linear furanocoumarin consumption associated with inhibition of cytochrome P450 1A2 isoenzyme activity in healthy human adults.

Zeyad Alehaideb, Sabine Matou-Nasri

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Emerging Biopharmaceuticals fromMolecules (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Zeyad AlehaidebKing Abdullah International Medical Research Center, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia.
Sabine Matou-NasriKing Abdullah International Medical Research Center, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia.
King Saud bin Abdulaziz University for Health Sciences · SANational Guard Health Affairs · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Millions of individuals globally consume traditional herbal medicines (THMs), which contain abundant amounts of linear furanocoumarins. Linear furanocoumarins (

Indexed as

5-MOP, 5-methoxypsoralen8-MOP, 8-methoxypsoralenAIC, Akaike’s information criterionBenchmark doseBMD, benchmark doseBMDL, BMD lower boundBMDS, BMD softwareBMDU, BMD upper boundBMR, benchmark responseCA, concentration-addition modelCaffeineCYP, cytochrome P450Cytochrome 1A2 enzymeDMSO, dimethyl sulfoxideFuranocoumarinHLM, human liver microsomesHPLC, high-performance liquid chromatographyIC50, concentration at 50 % inhibitionISOP, isopimpinellinLOAEL, lowest-observed-adverse-effect levellog10, common logMetabolismNADPH, β-nicotinamide adenine dinucleotide phosphate hydrogenNOAEL, no-observed-adverse-effect levelPOD, point-of-departureRPF, relative potency factorSD, standard deviationTCL, treated clearanceTHM, traditional herbal medicineTraditional herbal medicinesUCL, untreated clearanceUSEPA, United States Environmental Protection AgencyWM, whole-mixture model

Identifiers

PMID34377680
PMCPMC8329502
OpenAlexW3184223728

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.