Evidence map›Paper›PMID 34377675›Full record

ArticleMolecular genetics and metabolism reports2021

A neuropathological cell model derived from Niemann-Pick disease type C patient-specific iPSCs shows disruption of the p62/SQSTM1-KEAP1-NRF2 Axis and impaired formation of neuronal networks.

Ryo Saito, Takashi Miyajima, Takeo Iwamoto, Chen Wu, Ken Suzuki, Mohammad Arif Hossain, Miyo Munakata, Takumi Era, Yoshikatsu Eto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics and metabolism reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Niemann-Pick Disease Type C (NPDC) by Mutation ofAntioxidants (Basel, Switzerland) · 2023
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Ryo SaitoAdvanced Clinical Research Center, Southern Tohoku Research Institute for Neuroscience, 255 Furusawa, Asao-ku, Kawasaki 215-0026, Japan.
Takashi MiyajimaAdvanced Clinical Research Center, Southern Tohoku Research Institute for Neuroscience, 255 Furusawa, Asao-ku, Kawasaki 215-0026, Japan.
Takeo IwamotoAdvanced Clinical Research Center, Southern Tohoku Research Institute for Neuroscience, 255 Furusawa, Asao-ku, Kawasaki 215-0026, Japan.
Chen WuAdvanced Clinical Research Center, Southern Tohoku Research Institute for Neuroscience, 255 Furusawa, Asao-ku, Kawasaki 215-0026, Japan.
Ken SuzukiAdvanced Clinical Research Center, Southern Tohoku Research Institute for Neuroscience, 255 Furusawa, Asao-ku, Kawasaki 215-0026, Japan.
Mohammad Arif HossainAdvanced Clinical Research Center, Southern Tohoku Research Institute for Neuroscience, 255 Furusawa, Asao-ku, Kawasaki 215-0026, Japan.
Miyo MunakataAdvanced Clinical Research Center, Southern Tohoku Research Institute for Neuroscience, 7-115 Yatsuyamada, Koriyama, 963-8563, Japan.
Takumi EraDepartment of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.
Yoshikatsu EtoAdvanced Clinical Research Center, Southern Tohoku Research Institute for Neuroscience, 255 Furusawa, Asao-ku, Kawasaki 215-0026, Japan.
Jikei University School of Medicine · JPSouthern Tohoku General Hospital · JPAnges (Japan) · JPKumamoto University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Niemann-Pick disease type C (NPC) is a rare neurodegenerative disorder caused by a recessive mutation in the

Indexed as

Cell-based neuropathological modelInduced pluripotent stem cellsLysosomal storage disorderNeuronal network densityNiemann−Pick disease type Cp62/SQSTM1−KEAP1−NRF2 axis

Identifiers

PMID34377675
PMCPMC8327345
OpenAlexW3183853185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.