Evidence map›Paper›PMID 34377472›Full record

ArticleSAGE open medicine2021

A single-dose nitrate-producing dietary supplement affects cardiorespiratory endurance and muscular fitness in healthy men: A randomized controlled pilot trial.

Nikola Todorovic, Valdemar Stajer, Laszlo Ratgeber, Jozsef Betlehem, Pongrac Acs, Nebojsa Maksimovic, Sergej M Ostojic

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In one paragraph

Article in SAGE open medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nikola TodorovicFaculty of Sport and Physical Education, University of Novi Sad, Applied Bioenergetics Lab, Novi Sad, Serbia.
Valdemar StajerFaculty of Sport and Physical Education, University of Novi Sad, Applied Bioenergetics Lab, Novi Sad, Serbia.
Laszlo RatgeberFaculty of Health Sciences, University of Pecs, Pecs, Hungary.
Jozsef BetlehemFaculty of Health Sciences, University of Pecs, Pecs, Hungary.
Pongrac AcsFaculty of Health Sciences, University of Pecs, Pecs, Hungary.
Nebojsa MaksimovicFaculty of Sport and Physical Education, University of Novi Sad, Applied Bioenergetics Lab, Novi Sad, Serbia.
Sergej M OstojicFaculty of Sport and Physical Education, University of Novi Sad, Applied Bioenergetics Lab, Novi Sad, Serbia.ORCID https://orcid.org/0000-0002-7270-2541

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe main aim of this pilot study was to examine the effects of a single-dose intervention with a novel nitrate-producing formulation (MagNOVOx™) on biomarkers of cardiorespiratory endurance and muscular fitness in 12 healthy men.

methodsThe study participants (age = 22.7 ± 2.8 years, height = 184.1 ± 5.7 cm, and weight = 82.5 ± 8.4 kg) were randomly allocated to receive either a single dose of MagNOVOx™ or a placebo (inulin) in a cross-over design. The primary outcome for this study was the change in running time to exhaustion evaluated at baseline (before supplementation) and post-intervention.

resultsTime to exhaustion was improved after the intervention in 8 out of 11 participants (72.7%) who received MagNOVOx™, and in 1 out of 11 participants (9.1%) who received placebo (

conclusionThese promising findings should be further corroborated in medium- and long-term trials, and different populations, while the exact mechanism of MagNOVOx™ requires additional physiological studies.

Indexed as

blood pressureergogenicNitratetime to exhaustion

Identifiers

PMID34377472
PMCPMC8327001

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.