Evidence map›Paper›PMID 34377405›Full record

ArticleChemical science2021

Mechanical unfolding of ensemble biomolecular structures by shear force.

Changpeng Hu, Sagun Jonchhe, Pravin Pokhrel, Deepak Karna, Hanbin Mao

Abstract read
In one paragraph

Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Modulating a Massive Set of Biomolecular Structures by Sono-Mechanical Force.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Ensemble Force Spectroscopy by Shear Forces.Journal of visualized experiments : JoVE · 2022
    Article
  4. Single-Molecule Mechanochemical Sensing.Accounts of chemical research · 2022
    Article
  5. Article
  6. DNA origami nano-mechanics.Chemical Society reviews · 2021
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Changpeng HuDepartment of Chemistry & Biochemistry and School of Biomedical Sciences, Advanced Materials and Liquid Crystal Institute, Kent State University Kent OH 44242 USA hmao@kent.edu ppokhre1@kent.edu.
Sagun JonchheDepartment of Chemistry & Biochemistry and School of Biomedical Sciences, Advanced Materials and Liquid Crystal Institute, Kent State University Kent OH 44242 USA hmao@kent.edu ppokhre1@kent.edu.ORCID https://orcid.org/0000-0003-4361-6641
Pravin PokhrelDepartment of Chemistry & Biochemistry and School of Biomedical Sciences, Advanced Materials and Liquid Crystal Institute, Kent State University Kent OH 44242 USA hmao@kent.edu ppokhre1@kent.edu.
Deepak KarnaDepartment of Chemistry & Biochemistry and School of Biomedical Sciences, Advanced Materials and Liquid Crystal Institute, Kent State University Kent OH 44242 USA hmao@kent.edu ppokhre1@kent.edu.ORCID https://orcid.org/0000-0003-3370-0997
Hanbin MaoDepartment of Chemistry & Biochemistry and School of Biomedical Sciences, Advanced Materials and Liquid Crystal Institute, Kent State University Kent OH 44242 USA hmao@kent.edu ppokhre1@kent.edu.ORCID https://orcid.org/0000-0002-6720-9429

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanical unfolding of biomolecular structures has been exclusively performed at the single-molecule level by single-molecule force spectroscopy (SMFS) techniques. Here we transformed sophisticated mechanical investigations on individual molecules into a simple platform suitable for molecular ensembles. By using shear flow inside a homogenizer tip, DNA secondary structures such as i-motifs are unfolded by shear force up to 50 pN at a 77 796 s

Identifiers

PMID34377405
PMCPMC8336480

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.