ArticleAmerican journal of translational research2021
Cytokine expression in patients with interstitial lung disease in primary Sjogren's syndrome and its clinical significance.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- IFN-γ-Associated Signaling Networks in Interstitial Lung Disease Associated With Sjögren's Disease.Immunity, inflammation and disease · 2026Review
- Interleukin-6 as a Biomarker for Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Retrospective Study.International journal of general medicine · 2026Article
- A correlation study of serum tumor markers with systemic lupus erythematosus-associated interstitial lung disease.Frontiers in medicine · 2025Article
- Elevated Plasma CXCL8 Concentrations in Significant Fibrosis but Not in Subclinical Rejection After Adult Liver Transplantation.Transplantation direct · 2024Article
- TLR7 activation of age-associated B cells mediates disease in a mouse model of primary Sjögren's disease.Journal of leukocyte biology · 2024Article
- Human umbilical cord mesenchymal stem cells improve disease characterization of Sjogren's syndrome in NOD mice through regulation of gut microbiota and Treg/Th17 cellular immunity.Immunity, inflammation and disease · 2024Article
- Clinical significance of interleukin-6, total bilirubin, CD3 + CD4 + T cells counts in the acute exacerbation of connective tissue disease-associated interstitial lung disease: a cross-sectional study.European journal of medical research · 2023Article
- Clinically Relevant Biomarkers in Connective Tissue Disease-Associated Interstitial Lung Disease.Immunology and allergy clinics of North America · 2023Review
- Pirfenidone inhibits cell fibrosis in connective tissue disease-associated interstitial lung disease by targeting the TNF-α/STAT3/KL6 pathway.Journal of thoracic disease · 2022Article
- Potential Mechanisms of White Peony against Primary Sjögren's Syndrome Based on Network Pharmacology and Molecular Docking.Evidence-based complementary and alternative medicine : eCAM · 2022Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
purposeTo explore the cytokine expression level of interstitial lung disease in primary Sjogren's syndrome (ILD-pSS) patients and its clinical significance.
methods50 pSS patients in our hospital from Jan 2017 to Dec 2019 were selected as pSS group and separated into pSS-ILD (15 cases) and pSS-non-ILD (35 cases) based on whether patients had ILD or not. Then 20 healthy people who underwent physical examination at the same time were matched as a control group. The levels of IL-6, IL-8, IL-10 and TNF-α between the pSS-ILD group and the pSS-non-ILD group were compared. The efficacy of ILD in pSS patients based on the analysis of the IL-6, IL-8, IL-10, and TNF-α levels with ROC curves was evaluated.
resultsThe IL-6, IL-8, and TNF-α levels of patients in the pSS group were significantly higher than those in the control group. The IL-10 expression level in the pSS group was significantly lower than that in the control group (P<0.05). The IL-6, IL-8 and TNF-α expression levels of patients in the pSS-ILD group were higher than these in the pSS-non-ILD group. The IL-10 expression level in the pSS-ILD group was significantly lower than that in the pSS-non-ILD (P<0.05). The result of the ROC curve showed that the AUC of IL-6, IL-8, IL-10, and TNF-α were 0.667, 0.712, 0.894 and 0.733 respectively. Among them, the AUC of IL-10 was the largest (0.894, the sensitivity was 87.54%, the specificity was 78.63%, and cut off value was 5.162 pg/ml.
conclusionThe serum IL-6, IL-8, IL-10 and the cytokine TNF-α are closely related to the ILD in pSS patients. They may participate in the occurrence and development of the pSS-ILD in patients.
Indexed as
Identifiers
34377333PMC8340227W3192633864What OpenQuestion holds
Registered trials
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