ArticleAmerican journal of translational research2021
Effect of Shujin Xiaotong capsules combined with ultrashort wave therapy on pain and inflammatory cytokines in patients with chronic knee osteoarthritis.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Ultrashort wave therapy promotes traumatic brain injury recovery by suppressing neuroinflammation.Neural regeneration research · 2026Article
- Osteoarthritis: Epidemiology, Diagnosis, and Treatment.MedComm · 2026Review
- Progress in the research of thunder-fire moxibustion and warm acupunct ure-moxibustion combined with western medicine in treating knee osteoarthritis.Pakistan journal of medical sciences · 2025Review
- Hemophilia B With Intracranial Hemorrhage Rehabilitation in High-Dependency Unit: A Case Report.Clinical case reports · 2025Article
- Clinical efficacy of Osteoking in knee osteoarthritis therapy: a prospective, multicenter, non-randomized controlled study in China.Frontiers in pharmacology · 2024Article
- The current status of stimuli-responsive nanotechnologies on orthopedic titanium implant surfaces.Journal of nanobiotechnology · 2023Review
- Evaluation of the effect of physical therapy on pain and dysfunction of knee osteoarthritis based on fNIRS: a randomized controlled trial protocol.BMC musculoskeletal disorders · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effect of Shujin Xiaotong capsules combined with ultrashort wave therapy on pain, high-sensitivity C-reactive protein (hs-CRP) level and inflammatory cytokines in patients with chronic knee osteoarthritis.
methodsOne hundred and eighteen patients with chronic knee osteoarthritis included in this study were randomly divided into the control group (n=59) and the experimental group (n=59). The patients in the control group were treated with Shujin Xiaotong capsules, and the patients in the experimental group were treated with Shujin Xiaotong capsules combined with ultrashort wave therapy. The knee motion before and after treatment, pain and curative effect were evaluated by the Lysholm Scale, Mc-Gee Scale and Japanese Orthopaedic Association (JOA) Score, respectively. Color Doppler ultrasonography was performed to observe the blood flow in the synovium of knee joint. Serum inflammatory cytokines and oxidative stress indicators were measured using corresponding kits. The quality of life of the patients was measured using the World Health Organization Quality of Life-BREF Scale.
resultsThere was no significant difference in the scores of the Lysholm, Mc-Gee and JOA, synovial blood flow signal distribution, levels of hs-CRP, inflammatory cytokines, superoxide dismutase, malondialdehyde and nitric oxide as well as quality of life of patients between the two groups before treatment (all P>0.05). After treatment, the scores of Lysholm, JOA and World Health Organization Quality of Life-BREF as well as levels of superoxide dismutase in both groups were improved, while the scores of Mc-Gee as well as levels of hs-CRP, inflammatory cytokines, malondialdehyde and nitric oxide in both groups were decreased (all P<0.05). After treatment, compared with the control group, the proportion of synovial blood flow signal distribution and quality of life of patients in the experimental group were higher, while the levels of hs-CRP, inflammatory cytokines, superoxide dismutase, malondialdehyde and nitric oxide were lower (all P<0.05).
conclusionShujin Xiaotong capsules combined with physical ultrashort wave therapy can significantly reduce serum inflammation cytokines and hs-CRP expression and pain, as well as improve serum oxidative stress levels, knee joint function and quality of life in patients with chronic knee osteoarthritis.
Indexed as
Identifiers
34377291PMC8340228W3188756002What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.