ArticleAmerican journal of translational research2021
Effects of glucocorticoids on the levels of serum tumor necrosis factor alpha and interleukin 6 in patients with rheumatoid arthritis.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed, 0 citations in OpenAlex.
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe study was designed to explore the effects of glucocorticoid therapy on the levels of serum interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) in patients with rheumatoid arthritis (RA).
methodsClinical information of 100 patients with RA who were admitted to our hospital from 2015 to 2018 were retrospectively collected and divided into two groups according to the random number table method. Patients receiving routine treatment were classified as the control group (n = 50) and those receiving glucocorticoid therapy based on routine treatment were classified as the observation group (n = 50). Pre- and post-treatment clinical effects, tender joint counts, swollen joint counts; periods of morning stiffness, visual analog scale (VAS) scores, Disease Activity Score-28 (DAS28), erythrocyte sedimentation rate (ESR), and rheumatoid factor (RF), IL-6, and TNF-α levels were compared between the two groups.
resultsCompared with the control group, the observation group had a higher total effective rate. The observation group exhibited lower tender and swollen joint counts and shorter morning stiffness periods than the control group (
conclusionGlucocorticoids show beneficial effects on alleviating RA symptoms. Due to the limited sample size in the study, future studies with a larger cohort and over a longer investigation period are warranted to provide comprehensive results.
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Identifiers
34377267PMC8340212W3188617794What OpenQuestion holds
Registered trials
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