ArticleAmerican journal of translational research2021
Relationship between miR-29a levels in the peripheral blood and sepsis-related encephalopathy.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 6 of them syntheses that pooled it.
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The trial behind it
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Who cites it
10 citing papers in PubMed, 6 syntheses or guidelines pooled it, 10 citations in OpenAlex.
- Unveiling neurogenic biomarkers for the differentiation between sepsis patients with or without encephalopathy: an updated meta-analysis.Systematic reviews · 2025Pooled it
- Diagnostic utility of neurogenic biomarkers in differentiating sepsis with and without associated encephalopathy: a systematic review and meta-analytic approach.Frontiers in neurology · 2025Pooled it
- Significances of miRNAs for predicting sepsis mortality: a meta-analysis.Frontiers in microbiology · 2025Pooled it
- Clinical value of serum neuron-specific enolase in sepsis-associated encephalopathy: a systematic review and meta-analysis.Systematic reviews · 2024Pooled it
- Role of serum neuron-specific enolase levels in the early diagnosis and prognosis of sepsis-associated encephalopathy: a systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- Diagnostic and prognostic value of serum S100B in sepsis-associated encephalopathy: A systematic review and meta-analysis.Frontiers in immunology · 2023Pooled it
- Combined cerebral oxygen saturation and neuron-specific enolase evaluation for diagnosis and prognosis of sepsis-associated encephalopathy.Scientific reports · 2025Observational
- Paediatric sepsis-associated encephalopathy (SAE): a comprehensive review.Molecular medicine (Cambridge, Mass.) · 2023Review
- Septic encephalopathy in the elderly - biomarkers of potential clinical utility.Frontiers in cellular neuroscience · 2023Review
- Association Among the Gut Microbiome, the Serum Metabolomic Profile and RNA mFrontiers in genetics · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to explore the relationship between peripheral blood miR-29a and sepsis-related encephalopathy (SAE).
methodsA total of 120 patients with sepsis admitted to our hospital from March 2018 to October 2019 were selected as research subjects. They were divided into a SAE group (30 cases) and an unrelated encephalopathy group (90 cases) according to whether the patients were complicated with SAE. The levels of miR-29a in the peripheral blood, neuron-specific enolase (NSE), S100β calcium binding protein (S100β) and interleukin-6 (IL-6) in serum were determined, and the relationship between miR-29a in the peripheral blood and the diagnosis and prognosis prediction in SAE patients was analyzed.
resultsCompared with the unrelated encephalopathy group, the levels of miR-29a in peripheral blood, NSE, S100β and IL-6 in serum of patients in the SAE group were elevated notably. miR-29a in the peripheral blood, and NSE, S100β, IL-6 in the serum of patients who died and survived within 28 days were detected, and the levels of these four indexes in the death group were significantly higher than those in the survival group. Correlation analysis revealed that miR-29a in the peripheral blood was positively correlated with the levels of NSE, S100β and IL-6 in serum. According to Receiver Operating Characteristic (ROC) curve analysis, miR-29a in the peripheral blood can be used as a potential biomarker to predict whether sepsis is complicated with SAE and the relative prognosis.
conclusionmiR-29a is closely associated with the development of SAE, and miR-29a in the peripheral blood can be used as a potential biological index to predict whether sepsis is complicated with SAE and indications of a poor prognosis.
Indexed as
Identifiers
34377248PMC8340237W3190357795What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.