Evidence map›Paper›PMID 34376995›Full record

ArticleNutrition and metabolic insights2021

Effect of Regular Khat Chewing on Serum Fasting Sugar Level in Diabetic patients versus Healthy Individuals; A comparative study.

Yordanos Mengistu, Gobena Dedefo, Mesay Arkew, Gebeyehu Asefa, Gutema Jebessa, Abay Atnafu, Zerihun Ataro, Samuel Kinde

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition and metabolic insights, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yordanos MengistuDepartment of Medical Laboratory, School of Allied Health Sciences, Health Science College, Addis Ababa University, Ethiopia.
Gobena DedefoDepartment of Medical Laboratory, School of Allied Health Sciences, Health Science College, Addis Ababa University, Ethiopia.
Mesay ArkewDepartment of Medical Laboratory, College of Health and Medical Science, Haramaya University, Ethiopia.
Gebeyehu AsefaArmauer Hanson Research institute, Addis Ababa, Ethiopia.
Gutema JebessaArmauer Hanson Research institute, Addis Ababa, Ethiopia.
Abay AtnafuArmauer Hanson Research institute, Addis Ababa, Ethiopia.
Zerihun AtaroDepartment of Medical Laboratory, College of Health and Medical Science, Haramaya University, Ethiopia.
Samuel KindeDepartment of Medical Laboratory, School of Allied Health Sciences, Health Science College, Addis Ababa University, Ethiopia.
Addis Ababa University · ETArmauer Hansen Research Institute · ETHaramaya University · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKhat chewing is a long standing social-cultural habit in several countries. Even though many people chew khat simply for its pleasurable and stimulatory effect, evidence showed widely-held belief among khat chewers in Ethiopia and other part of the world that khat helps to lower blood glucose while some studies are contradicted on the effect of khat. There is limited data about khat's effect on blood glucose especially in our setting, Harar estern Ethiopia.

objectivePrimarily the present study aims to compare fasting blood sugar level among khat chewer diabetic and healthy individuals, and to asses risk factors associated with poor glycemic control in diabetic subjects.

methodA cross-sectional study included 200 confirmed diabetic and healthy subjects. Fasting blood sugar was determined by enzymatic method glucose oxidase and glucose hexokinase. Glycemic control was also determined for diabetic subjects based on the last 2-month diabetic clinic visits and current measurement.

result(Median ± IQR [interquartile range]) fasting blood sugar difference among Khat chewer and non khat chewer were 159 ± 83 mg/dl and 202 ± 79 mg/dl respectively in diabetic subjects when tested by glucose oxidase. Similarly, in healthy non khat chewer and khat chewer, khat chewers has lower (Median ± IQR) fasting blood glucose level 82 ± 18 mg/dl than non khat chewers 94 ± 13 mg/dl when tested by glucose oxidase. Regarding risk factors associated with poor glycemic control in diabetic subjects, positive parental diabetes history, insulin medication, being overweight, obese were significantly associated with poor glycemic control.

conclusionThere was significant effect of khat on median FBS among khat chewers in diabetic and healthy individuals. And the proportion of glycemic control was high among diabetic subjects. RECOMMENDATION: Health care professional and patients should manage the risk factors to delay disease progression and restrain the damage. More studies should be conducted in randomized control trial manner to further elucidate khat effect on blood sugar level so that the actual effect of khat can be identified unlike in cross sectional where there may not be strong causal relationship.

Indexed as

Diabetes mellitusFasting blood sugarKhatRisk factors

Identifiers

PMID34376995
PMCPMC8320567
OpenAlexW3183313975

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.