Evidence map›Paper›PMID 34376972›Full record

Trial reportDrug design, development and therapy2021

Effect of Intravenous Lidocaine on Serum Interleukin-17 After Video-Assisted Thoracic Surgery for Non-Small-Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial.

Yong-Heng Hou, Wen-Cheng Shi, Shu Cai, Hong Liu, Zhong Zheng, Fu-Wei Qi, Chang Li, Xiao-Mei Feng, Ke Peng, Fu-Hai Ji

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug design, development and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06289790 (Analgesic Efficacy of Erector Spinae Plane), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06289790 nacompletednot on this mapstarted 2024, after this paper: background citation

Analgesic Efficacy of Erector Spinae Plane (ESP) Block vs Intravenous Lignocaine Infusion in Video- Assisted Thoracoscopy (VATS)

TypeinterventionalSponsorCentral Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, PolandRan2024 to 2025Enrolled61ConditionsThoracic Surgery, Video-AssistedArmsErector Spinae Plane (ESP) block, Lignocaine, Bupivacaine
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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  10. Anesthesia and cancer recurrence: a narrative review.Anesthesia and pain medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Yong-Heng Hou *Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Wen-Cheng Shi *Department of Anesthesiology, Taicang First People's Hospital, Taicang Affiliated Hospital of Soochow University, Taicang, Jiangsu, People's Republic of China.
Shu Cai *Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Hong LiuDepartment of Anesthesiology and Pain Medicine, University of California Davis Health, Sacramento, CA, USA.ORCID 0000-0003-3611-7131
Zhong ZhengDepartment of Anesthesiology, Taicang First People's Hospital, Taicang Affiliated Hospital of Soochow University, Taicang, Jiangsu, People's Republic of China.
Fu-Wei QiDepartment of Anesthesiology, Taicang First People's Hospital, Taicang Affiliated Hospital of Soochow University, Taicang, Jiangsu, People's Republic of China.
Chang LiDepartment of Thoracic Surgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Xiao-Mei FengDepartment of Anesthesiology, University of Utah health, Salt Lake City, UT, USA.
Ke PengDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.ORCID 0000-0003-2879-1759
Fu-Hai JiDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.ORCID 0000-0001-6649-665X
Soochow University · CNUniversity of California, Davis · USUniversity of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSurgical stress promotes tumor metastasis. Interleukin (IL)-17 plays a pivotal role in cancer progression, and high IL-17 expression predicts poor prognosis of non-small-cell lung cancer (NSCLC). Lidocaine may exert tumor-inhibiting effects. We hypothesize that intravenous lidocaine attenuates surgical stress and reduces serum IL-17 levels during video-assisted thoracic surgery (VATS) for NSCLC.

methodsThis randomized, double-blind, placebo-controlled trial included 60 early-stage NSCLC patients undergoing VATS, into a lidocaine group (n = 30; intravenous lidocaine bolus 1.0 mg/kg, and 1.0 mg/kg/h until the end of surgery) or a normal saline control group (n = 30). The primary outcome was serum IL-17 level at 24 hours postoperatively. The secondary outcomes included serum IL-17 level at the time of post-anesthesia care unit (PACU) discharge, serum cortisol level at PACU discharge and postoperative 24 hours, pain scores (0-10) from PACU discharge to 48 hours postoperatively, incidences of postoperative nausea and vomiting, dizziness, and arrhythmia during 0-48 hours postoperatively, and 30-day mortality. Long-term outcomes included chemotherapy, cancer recurrence, and mortality.

resultsThe lidocaine group had lower serum IL-17 at 24 hours postoperatively compared with the control group (23.0 ± 5.8 pg/mL vs 27.3 ± 8.2 pg/mL, difference [95% CI] = -4.3 [-8.4 to -0.2] pg/mL;

conclusionIntravenous lidocaine was associated with reduced serum IL-17 and cortisol following VATS procedures in early-stage NSCLC patients.

trial registrationChiCTR2000030629.

Indexed as

AdultAnesthetics, LocalCarcinoma, Non-Small-Cell LungDouble-Blind MethodFemaleFollow-Up StudiesHumansHydrocortisoneInterleukin-17LidocaineLung NeoplasmsMaleMiddle AgedStress, PhysiologicalThoracic Surgery, Video-AssistedAnesthetics, LocalHydrocortisoneIL17A protein, humanInterleukin-17Lidocaineinterleukin-17lidocainenon-small-cell lung cancersurgical stressvideo-assisted thoracic surgery

Identifiers

PMID34376972
PMCPMC8349198
OpenAlexW3190656115

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.