Evidence map›Paper›PMID 34376834›Full record

ReviewNature reviews. Neuroscience2021

Advancing models of neural development with biomaterials.

Julien G Roth, Michelle S Huang, Thomas L Li, Vivian R Feig, Yuanwen Jiang, Bianxiao Cui, Henry T Greely, Zhenan Bao, Sergiu P Paşca, Sarah C Heilshorn

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. Review
  2. Review
  3. Temporal Interference Stimulation Enhances Neural Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. 3DMaterials today. Bio · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Bioengineering tools for next-generation neural organoids.Current opinion in neurobiology · 2025
    Review
  17. Hybrid fibres: a new path in tissue regeneration.Journal of materials science. Materials in medicine · 2025
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julien G RothInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-7560-3258
Michelle S HuangDepartment of Chemical Engineering, Stanford University, Stanford, CA, USA.ORCID 0000-0002-1814-7786
Thomas L LiDepartment of Chemistry, Stanford University, Stanford, CA, USA.ORCID 0000-0002-8656-0679
Vivian R FeigDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
Yuanwen JiangDepartment of Chemical Engineering, Stanford University, Stanford, CA, USA.
Bianxiao CuiDepartment of Chemistry, Stanford University, Stanford, CA, USA.
Henry T GreelyStanford Law School, Stanford University, Stanford, CA, USA.ORCID 0000-0002-1105-6734
Zhenan BaoDepartment of Chemical Engineering, Stanford University, Stanford, CA, USA.
Sergiu P PaşcaDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3216-3248
Sarah C HeilshornDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA. heilshorn@stanford.edu.ORCID 0000-0002-9801-6304

Funding

Injectable Hydrogels to Protect Transplanted Cells from HypoxiaR01EB027666 · NIBIB · STANFORD UNIVERSITY · PI HEILSHORN, SARAH C, PLANT, GILES · 2019 to 2022
$1.4M
Engineered biomaterials to modulate cell-cell signaling for the robust expansion of stem cellsR01EB027171 · NIBIB · STANFORD UNIVERSITY · PI HEILSHORN, SARAH C · 2019 to 2022
$1.4M
Combinatorial matrix-mimetic recombinant proteins as engineered nerve guidance conduitsR21NS114549 · NINDS · STANFORD UNIVERSITY · PI GEORGE, PAUL, HASTIE, TREVOR J. · 2020 to 2020
$436k
NIBIB NIH HHS R01 EB027171NIBIB NIH HHS R01 EB027666NINDS NIH HHS R21 NS114549
6 · The paper itself

Abstract

Human pluripotent stem cells have emerged as a promising in vitro model system for studying the brain. Two-dimensional and three-dimensional cell culture paradigms have provided valuable insights into the pathogenesis of neuropsychiatric disorders, but they remain limited in their capacity to model certain features of human neural development. Specifically, current models do not efficiently incorporate extracellular matrix-derived biochemical and biophysical cues, facilitate multicellular spatio-temporal patterning, or achieve advanced functional maturation. Engineered biomaterials have the capacity to create increasingly biomimetic neural microenvironments, yet further refinement is needed before these approaches are widely implemented. This Review therefore highlights how continued progression and increased integration of engineered biomaterials may be well poised to address intractable challenges in recapitulating human neural development.

Indexed as

AnimalsBiocompatible MaterialsBrainCell DifferentiationExtracellular MatrixHumansNeural Stem CellsNeurogenesisPluripotent Stem CellsBiocompatible Materials

Identifiers

PMID34376834
PMCPMC8612873

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.