ReviewNature reviews. Endocrinology2021
Challenges in the care of transgender and gender-diverse youth: an endocrinologist's view.
Review in Nature reviews. Endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Pharmacological Therapy in Patients With Gender Dysphoria: A Cohort Study in the Lazio Region, Italy.Pharmacoepidemiology and drug safety · 2026Article
- Management of andrological disorders from childhood and adolescence to transition age: guidelines from the Italian Society of Andrology and Sexual Medicine (SIAMS) in collaboration with the Italian Society for Pediatric Endocrinology and Diabetology (SIEDP) - part-2.Journal of endocrinological investigation · 2026Article
- When algorithms infer gender: revisiting computational phenotyping with electronic health records data.Biology of sex differences · 2025Review
- Pubertal Suppression for Transgender Youth: A Right to an Open Future Approach in Support of a Youth-Empowered Legal Framework.Journal of bioethical inquiry · 2025Article
- Social and biological factors related to gender expression in 3-year-old children.Endocrine connections · 2025Article
- Individualized and innovative gender healthcare for transgender and nonbinary youth.Nature reviews. Endocrinology · 2025Review
- Emerging and accumulating safety signals for the use of estrogen among transgender women.Discover mental health · 2025Review
- Psychosocial Correlates of Gender-Affirming Hormone and Medically Necessary Surgical Intervention (MNSI) Use among Transgender and Gender Diverse Youth and Young Adults.Psychology of sexual orientation and gender diversity · 2025Article
- Clinicians Report Less Comfort in Provision of Medical Care to Nonbinary Transgender Youth.Transgender health · 2025Article
- Genetic Analyses on Transgender Individuals: Impact on Physician Attitudes and Surgical Decision-Making.Brain and behavior · 2025Article
- Multi-Stakeholder Opinion Statement on the Care of Individuals Born with Differences of Sex Development: Common Ground and Opportunities for Improvement.Hormone research in paediatrics · 2025Article
- Exogenous Hormone Use Among Transfeminine Individuals in Chiang Mai, Thailand.Transgender health · 2024Article
- Another Myth of Persistence?Archives of sexual behavior · 2024Article
- Puberty Suppression for Pediatric Gender Dysphoria and the Child's Right to an Open Future.Archives of sexual behavior · 2024Article
- White matter microstructure in transmasculine and cisgender adolescents: A multiparametric and multivariate study.PloS one · 2024Article
- Epigenetic mechanisms underlying sex differences in the brain and behavior.Trends in neurosciences · 2024Review
- The Detransition Rate Is Unknown.Archives of sexual behavior · 2023Article
- Prevalence of cancer risk factors among transgender and gender diverse individuals: a cross-sectional analysis using UK primary care data.The British journal of general practice : the journal of the Royal College of General Practitioners · 2023Article
- Transition Regret and Detransition: Meanings and Uncertainties.Archives of sexual behavior · 2023Article
- Gender Diversity and Brain Morphology Among Adolescents.JAMA network open · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
An increasing number of transgender and gender-diverse (TGD) youth (early pubertal through to late adolescent, typically 9-10 through to 18 years of age) are seeking medical services to bring their physical sex characteristics into alignment with their gender identity - their inner sense of self as male or female or somewhere on the gender spectrum. Compelling research has demonstrated the clear mental health - even life-saving - benefits of gender-affirming care, but current clinical practice guidelines and standards of care are based on only several short-term and a few medium-term outcomes studies complemented by expert opinion. Nevertheless, although the relative paucity of outcomes data raises concerns, the stance of not intervening until more is known is not a neutral option, and large observational studies evaluating current models of care are necessary and are now underway. This Review highlights key advances in our understanding of transgender and gender-diverse youth, the challenges of providing gender-affirming care, gaps in knowledge and priorities for research.
Indexed as
Identifiers
34376826What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.