ArticleCommunications biology2021
Spectral dynamic causal modelling in healthy women reveals brain connectivity changes along the menstrual cycle.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- A systematic review of resting-state EEG across the menstrual cycle and its mental health relevance.Archives of women's mental health · 2026Pooled it
- Triple network model of brain connectivity changes related to adverse mood effects in an oral contraceptive placebo-controlled trial.Translational psychiatry · 2023Trial
- Distinct Brain Drivers and Shared Cerebello-Cortical Input in ADCY5 and SGCE Hyperkinetic Movements.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Distinct intrinsic neural connectivity of an emotion regulation network across the menopausal transition.Comprehensive psychoneuroendocrinology · 2026Article
- The interplay of central insulin and menstrual cycle on functional brain networks and neural food cue reactivity in women.Communications biology · 2026Article
- Clinical efficacy and mechanism exploration of Moxibustion for diminished ovarian reserve: a randomized controlled trial protocol.Frontiers in public health · 2026Article
- Menstrual cycle variations in stress vulnerability and sociability relate to mental health symptoms and libido.npj women's health · 2026Article
- Hormonal contraceptives impair psychomotor vigilance task performance under sleep deprivation with stress induction.Sleep advances : a journal of the Sleep Research Society · 2026Article
- A standardized non-linear approach to studying menstrual cycle effects on brain and behavior.Frontiers in cognition · 2026Article
- Effective Connectivity Alterations of Directed Brain Network in Pediatric Patients With Spinal Cord Injury.CNS neuroscience & therapeutics · 2025Article
- A Novel Investigation of an In-Scanner Alternative to the Cold Pressor Test in Healthy Individuals.Human brain mapping · 2025Article
- Decreases in Hormone Levels Modulate Neurovascular Coupling but Not Reduced Insular Functional Connectivity in Menstrual-Related Migraine.Human brain mapping · 2025Article
- Posttraumatic Stress Disorder-Related Differences in Neural Connectivity Among Female Trauma Survivors.Biological psychiatry global open science · 2025Article
- Exploring neuroendocrine influences on the sensorimotor-association axis in a female and a male individual.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Idiosyncrasy and generalizability of contraceptive- and hormone-related functional connectomes across the menstrual cycle.Network neuroscience (Cambridge, Mass.) · 2025Article
- Effective connectivity analysis of response inhibition functional network.Frontiers in neuroscience · 2025Article
- PTSD-related differences in resting-state functional connectivity and associations with sex hormones.medRxiv : the preprint server for health sciences · 2024Article
- Aberrant Brain Triple-Network Effective Connectivity Patterns in Type 2 Diabetes Mellitus.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024Article
- Spotlighting SHAPERS: sex hormones associated with psychological and endocrine roles.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Aberrant brain functional hubs and causal effective connectivity in menstrually-related and non-menstrually-related migraine without aura.Quantitative imaging in medicine and surgery · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
Longitudinal menstrual cycle studies allow to investigate the effects of ovarian hormones on brain organization. Here, we use spectral dynamic causal modelling (spDCM) in a triple network model to assess effective connectivity changes along the menstrual cycle within and between the default mode, salience and executive control networks (DMN, SN, and ECN). Sixty healthy young women were scanned three times along their menstrual cycle, during early follicular, pre-ovulatory and mid-luteal phase. Related to estradiol, right before ovulation the left insula recruits the ECN, while the right middle frontal gyrus decreases its connectivity to the precuneus and the DMN decouples into anterior/posterior parts. Related to progesterone during the mid-luteal phase, the insulae (SN) engage to each other, while decreasing their connectivity to parietal ECN, which in turn engages the posterior DMN. When including the most confident connections in a leave-one out cross-validation, we find an above-chance prediction of the left-out subjects' cycle phase. These findings corroborate the plasticity of the female brain in response to acute hormone fluctuations and may help to further understand the neuroendocrine interactions underlying cognitive changes along the menstrual cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.