ArticleCommunications biology2021
Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed.
- Miniature endoscope for high resolution electrophysiological recordings from the colon of live mice.Nature communications · 2026Article
- Enteric glial S100B controls rhythmic colonic functions by regulating excitability and specificity in gut motor neurocircuits.The Journal of physiology · 2025Article
- Autonomic effects of electroacupuncture in opioid-induced constipation in male rats.Physiological reports · 2025Article
- Article
- Ancient emergence of neuronal heterogeneity in the enteric nervous system of jawless vertebrates.Developmental biology · 2025Article
- Review
- Novel insights into mechanisms of inhibition of colonic motility by loperamide.Frontiers in neuroscience · 2024Article
- Long-Term Implicit Epigenetic Stress Information in the Enteric Nervous System and its Contribution to Developing and Perpetuating IBS.Current neuropharmacology · 2024Review
- Intestinal distension orchestrates neuronal activity in the enteric nervous system of adult mice.The Journal of physiology · 2023Article
- The enteric nervous system.Physiological reviews · 2023Review
- Review
- Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice.Communications biology · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
How the Enteric Nervous System (ENS) coordinates propulsion of content along the gastrointestinal (GI)-tract has been a major unresolved issue. We reveal a mechanism that explains how ENS activity underlies propulsion of content along the colon. We used a recently developed high-resolution video imaging approach with concurrent electrophysiological recordings from smooth muscle, during fluid propulsion. Recordings showed pulsatile firing of excitatory and inhibitory neuromuscular inputs not only in proximal colon, but also distal colon, long before the propagating contraction invades the distal region. During propulsion, wavelet analysis revealed increased coherence at ~2 Hz over large distances between the proximal and distal regions. Therefore, during propulsion, synchronous firing of descending inhibitory nerve pathways over long ranges aborally acts to suppress smooth muscle from contracting, counteracting the excitatory nerve pathways over this same region of colon. This delays muscle contraction downstream, ahead of the advancing contraction. The mechanism identified is more complex than expected and vastly different from fluid propulsion along other hollow smooth muscle organs; like lymphatic vessels, portal vein, or ureters, that evolved without intrinsic neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.