Evidence map›Paper›PMID 34376664›Full record

ArticleNature communications2021

Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice.

Edd Ricker, Michela Manni, Danny Flores-Castro, Daniel Jenkins, Sanjay Gupta, Juan Rivera-Correa, Wenzhao Meng, Aaron M Rosenfeld, Tania Pannellini, Mahesh Bachu and 5 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 108 citations in OpenAlex.

  1. Sex-dependent mechanisms in rheumatic diseases.Nature reviews. Rheumatology · 2026
    Review
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  11. Extrafollicular and other non-germinal center B cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
  12. The multilayered identity of B cell memory.Cellular & molecular immunology · 2026
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Edd RickerAutoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, USA.
Michela ManniAutoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, USA.
Danny Flores-CastroAutoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, USA.
Daniel JenkinsAutoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, USA.
Sanjay GuptaAutoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, USA.
Juan Rivera-CorreaAutoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, USA.
Wenzhao MengDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA, USA.
Aaron M RosenfeldDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-2266-0355
Tania PannelliniResearch Division and Precision Medicine Laboratory, Hospital for Special Surgery, New York, NY, USA.
Mahesh BachuArthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, USA.
Yurii ChinenovDavid Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.
Peter K SculcoDepartment of Orthopedic Surgery, Hospital for Special Surgery, New York, NY, USA.
Rolf JessbergerInstitute of Physiological Chemistry, Technische Universitat, Dresden, Germany.ORCID 0000-0002-2972-2192
Eline T Luning PrakDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-9478-9211
Alessandra B PernisAutoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, USA. pernisa@hss.edu.ORCID 0000-0001-8259-1446
Hospital for Special Surgery · USTechnische Universität Dresden · DE

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3M
HSS Research Institute Rheumatology TrainingT32AR071302 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI ALESSANDRA B PERNIS, Jane E Salmon · 2017 to 2026
$2.3M
Novel signaling pathways in lupus pathogenesisR01AR064883 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI PERNIS, ALESSANDRA B · 2015 to 2019
$1.9M
Regulatory Mechanisms Controlling TFH Responses in LupusR01AR070146 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI PERNIS, ALESSANDRA B · 2016 to 2020
$1.9M
Cell SorterS10OD019986 · OD · HOSPITAL FOR SPECIAL SURGERY · PI LU, THERESA T. · 2015 to 2015
$600k
NCI NIH HHS P30 CA016520NIAMS NIH HHS R01 AR064883NIAMS NIH HHS R01 AR070146NIAMS NIH HHS T32 AR071302NIH HHS S10 OD019986
6 · The paper itself

Abstract

Differences in immune responses to viruses and autoimmune diseases such as systemic lupus erythematosus (SLE) can show sexual dimorphism. Age-associated B cells (ABC) are a population of CD11c

Indexed as

Age FactorsAgingAnimalsB-LymphocytesCD11c AntigenCell DifferentiationCells, CulturedDNA-Binding ProteinsFemaleGuanine Nucleotide Exchange FactorsKaplan-Meier EstimateLupus Erythematosus, SystemicMaleMiceMice, Inbred C57BLMice, KnockoutCD11c AntigenDef6 protein, mouseDNA-Binding ProteinsGuanine Nucleotide Exchange FactorsMinor Histocompatibility AntigensNuclear ProteinsSwap70 protein, mouseT-bet Transcription FactorT-Box Domain Proteins

Identifiers

PMID34376664
PMCPMC8355159
OpenAlexW3193171813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.