ArticleNature communications2021
Choice-relevant information transformation along a ventrodorsal axis in the medial prefrontal cortex.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Accumulation of virtual tokens towards a jackpot reward enhances performance and value encoding in dorsal anterior cingulate cortex.Nature communications · 2026Article
- Anterior cingulate neurons combine outcome monitoring of past decisions with ongoing movement signals.Nature communications · 2026Article
- Neural geometry in the human hippocampus enables generalization across spatial position and gaze.ArXiv · 2026Article
- Rethinking the centrality of brain areas in understanding functional organization.Nature neuroscience · 2026Review
- Orbitofrontal High-Gamma Reflects Spike-Dissociable Value and Decision Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Rational inattention in neural coding for economic choice.bioRxiv : the preprint server for biology · 2024Article
- Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex.Nature communications · 2024Article
- Neural timescales reflect behavioral demands in freely moving rhesus macaques.Nature communications · 2024Article
- Cortical timescales and the modular organization of structural and functional brain networks.Human brain mapping · 2024Article
- Hierarchical action encoding in prefrontal cortex of freely moving macaques.Cell reports · 2023Article
- Widespread coding of navigational variables in prefrontal cortex.Current biology : CB · 2023Article
- Dorsal raphe neurons signal integrated value during multi-attribute decision-making.bioRxiv : the preprint server for biology · 2023Article
- Abstract Value Encoding in Neural Populations But Not Single Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neural timescales reflect behavioral demands in freely moving rhesus macaques.bioRxiv : the preprint server for biology · 2023Article
- A quadruple dissociation of reward-related behaviour in mice across excitatory inputs to the nucleus accumbens shell.Communications biology · 2023Article
- Automated pose estimation in primates.American journal of primatology · 2022Review
- The PRO model accounts for the anterior cingulate cortex role in risky decision-making and monitoring.Cognitive, affective & behavioral neuroscience · 2022Article
- Theory of the Multiregional Neocortex: Large-Scale Neural Dynamics and Distributed Cognition.Annual review of neuroscience · 2022Review
- The Promise of Behavioral Tracking Systems for Advancing Primate Animal Welfare.Animals : an open access journal from MDPI · 2022Review
- A structural and functional subdivision in central orbitofrontal cortex.Nature communications · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Choice-relevant brain regions in prefrontal cortex may progressively transform information about options into choices. Here, we examine responses of neurons in four regions of the medial prefrontal cortex as macaques performed two-option risky choices. All four regions encode economic variables in similar proportions and show similar putative signatures of key choice-related computations. We provide evidence to support a gradient of function that proceeds from areas 14 to 25 to 32 to 24. Specifically, we show that decodability of twelve distinct task variables increases along that path, consistent with the idea that regions that are higher in the anatomical hierarchy make choice-relevant variables more separable. We also show progressively longer intrinsic timescales in the same series. Together these results highlight the importance of the medial wall in choice, endorse a specific gradient-based organization, and argue against a modular functional neuroanatomy of choice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.