Evidence map›Paper›PMID 34376656›Full record

ArticleNature communications2021

Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health.

Thi Phuong Nam Bui, Louise Mannerås-Holm, Robert Puschmann, Hao Wu, Antonio Dario Troise, Bart Nijsse, Sjef Boeren, Fredrik Bäckhed, Dorothea Fiedler, Willem M deVos

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06661044 (Exploiting Human Microbiota-associated in Vivo Models for Mechanistic Studies to Understand the Benefits of Dietary Fibre Supplementation in Patients With Prostate Cancer), which is not on this map. Cited by 127 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 4 pooled it
36.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06661044 completednot on this mapstarted 2024, after this paper: background citation

Exploiting Human Microbiota-associated in Vivo Models for Mechanistic Studies to Understand the Benefits of Dietary Fibre Supplementation in Patients With Prostate Cancer

TypeobservationalSponsorUniversity of AberdeenRan2024 to 2025Enrolled6ConditionsProstate Cancer (Adenocarcinoma)
3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 4 syntheses or guidelines pooled it, 222 citations in OpenAlex.

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67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 7 countries.

Thi Phuong Nam BuiLaboratory of Microbiology, Wageningen University, Wageningen, The Netherlands. nam.bui@wur.nl.ORCID 0000-0001-5366-5960
Louise Mannerås-HolmThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Robert PuschmannLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.
Hao WuThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Antonio Dario TroiseProteomics & Mass Spectrometry Laboratory, ISPAAM, National Research Council, Portici, NA, Italy.
Bart NijsseLaboratory of Microbiology, Wageningen University, Wageningen, The Netherlands.
Sjef BoerenLaboratory of Biochemistry, Wageningen University, Wageningen, The Netherlands.ORCID 0000-0002-0847-8821
Fredrik BäckhedThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Dorothea FiedlerLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.ORCID 0000-0002-0798-946X
Willem M deVosLaboratory of Microbiology, Wageningen University, Wageningen, The Netherlands. willem.devos@wur.nl.ORCID 0000-0002-0273-3166
Humboldt-Universität zu Berlin · DEWageningen University & Research · NLFudan University · CNIstituto per il Sistema Produzione Animale in Ambiente Mediterraneo · ITRoosevelt Institute for American Studies · NLUniversity of Copenhagen · DKUniversity of Gothenburg · SEUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe the anaerobic conversion of inositol stereoisomers to propionate and acetate by the abundant intestinal genus Anaerostipes. A inositol pathway was elucidated by nuclear magnetic resonance using [

Indexed as

AcetatesAnimalsDietEubacterialesFecesHost Microbial InteractionsHumansInositolIntestinesMagnetic Resonance SpectroscopyMaleMiceMice, Inbred C57BLPhytic AcidPropionatesTandem Mass SpectrometryAcetatesInositolPhytic AcidPropionates

Identifiers

PMID34376656
PMCPMC8355322
OpenAlexW3189885969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.