Evidence map›Paper›PMID 34376649›Full record

ArticleNature communications2021

Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts.

Xiaojie Gao, Franziska Bender, Heun Soh, Changwan Chen, Mahsa Altafi, Sebastian Schütze, Matthias Heidenreich, Maria Gorbati, Mihaela-Anca Corbu, Marta Carus-Cadavieco and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. KCNQ2/3 Gain-of-Function Variants and Cell Excitability: Differential Effects in CA1 versus L2/3 Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  4. Review
  5. Article
  6. KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Xiaojie Gao *Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
Franziska Bender *Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
Heun SohUniversity of Connecticut, Storrs, CT, USA.
Changwan ChenMax Planck Institute for Metabolism Research, Cologne, Germany.
Mahsa AltafiInstitute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Sebastian SchützeLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
Matthias HeidenreichLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
Maria GorbatiLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
Mihaela-Anca CorbuMax Planck Institute for Metabolism Research, Cologne, Germany.ORCID http://orcid.org/0000-0001-7300-8714
Marta Carus-CadaviecoLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
Tatiana KorotkovaLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
Anastasios V TzingounisUniversity of Connecticut, Storrs, CT, USA.
Thomas J JentschLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany. jentsch@fmp-berlin.de.ORCID http://orcid.org/0000-0002-3509-2553
Alexey PonomarenkoLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany. alexey.ponomarenko@fau.de.ORCID http://orcid.org/0000-0002-5185-0107
Leibniz-Forschungsinstitut für Molekulare Pharmakologie · DEMax Delbrück Center · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversity of Cologne · DEUniversity of Connecticut · USMax Planck Institute for Metabolism Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hippocampal pyramidal cells encode an animal's location by single action potentials and complex spike bursts. These elementary signals are believed to play distinct roles in memory consolidation. The timing of single spikes and bursts is determined by intrinsic excitability and theta oscillations (5-10 Hz). Yet contributions of these dynamics to place fields remain elusive due to the lack of methods for specific modification of burst discharge. In mice lacking Kcnq3-containing M-type K

Indexed as

Action PotentialsAnimalsHippocampusHumansKCNQ3 Potassium ChannelMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicOptogeneticsPyramidal CellsTheta RhythmKCNQ3 Potassium ChannelKcnq3 protein, mouse

Identifiers

PMID34376649
PMCPMC8355348
OpenAlexW3190079148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.