Evidence map›Paper›PMID 34376571›Full record

ArticleScience signaling2021

Differential regulation of G protein signaling in

Justin M Watkins, Timothy J Ross-Elliott, Xiaoyi Shan, Fei Lou, Bernd Dreyer, Meral Tunc-Ozdemir, Haiyan Jia, Jing Yang, Celio Cabral Oliveira, Luguang Wu and 4 more

Open access · greenAbstract read
In one paragraph

Article in Science signaling, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Justin M WatkinsDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0003-4127-1950
Timothy J Ross-ElliottDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-0991-9588
Xiaoyi ShanDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Fei LouDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Bernd DreyerDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-8360-3269
Meral Tunc-OzdemirDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Haiyan JiaDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Jing YangDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Celio Cabral OliveiraDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-0885-5308
Luguang WuSchool of Agriculture and Food Science, University of Queensland, St. Lucia, Queensland Q4072, Australia.
Yuri TrusovSchool of Agriculture and Food Science, University of Queensland, St. Lucia, Queensland Q4072, Australia.ORCID 0000-0001-8215-5492
Timothy D SchwochertDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Patrick KrysanDepartment of Horticulture, University of Wisconsin Madison, Madison, WI 53706, USA.ORCID 0000-0003-4916-915X
Alan M JonesDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. alan_jones@unc.edu.ORCID 0000-0002-2365-6462
University of North Carolina at Chapel Hill · USThe University of Queensland · AUUniversity of Wisconsin–Madison · US

Funding

SEEDING POSTDOCTORAL INNOVATORS IN RESEARCH &EDUCATIONK12GM000678 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DONALD T LYSLE, Kathryn Joanna Reissner · 1999 to 2026
$30.9M
Novel Mechanisms Regulating the Heterotrimeric G Protein ComplexR01GM065989 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JONES, ALAN M. · 2002 to 2023
$5.5M
NIGMS NIH HHS K12 GM000678NIGMS NIH HHS R01 GM065989
6 · The paper itself

Abstract

In animals, endocytosis of a seven-transmembrane GPCR is mediated by arrestins to propagate or arrest cytoplasmic G protein-mediated signaling, depending on the bias of the receptor or ligand, which determines how much one transduction pathway is used compared to another. In

Indexed as

ArabidopsisArabidopsis ProteinsAnimalsArrestinsbeta-ArrestinsEndocytosisGTP-Binding ProteinsReceptors, G-Protein-CoupledRGS ProteinsSignal TransductionArabidopsis ProteinsArrestinsbeta-ArrestinsGTP-Binding ProteinsReceptors, G-Protein-CoupledRGS1 protein, ArabidopsisRGS Proteins

Identifiers

PMID34376571
PMCPMC8532171
OpenAlexW3190045137

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.