ArticleInternational journal of spine surgery2021
Demineralized Bone Matrix in Spine Surgery: A Review of Current Applications and Future Trends.
Article in International journal of spine surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Ceramic bone graft substitute vs autograft in XLIF: a prospective randomized single-center evaluation of radiographic and clinical outcomes.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Trial
- Fracture healing: from molecular and cellular mechanisms to therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Is a central cavity necessary for bioactive glass-ceramic spacers in plated ACDF? A retrospective comparison of solid versus cavity designs.Archives of orthopaedic and trauma surgery · 2026Article
- A bone graft substitute is effective for posterior spinal fusion in patients with juvenile or adolescent idiopathic scoliosis: a retrospective study.Journal of spine surgery (Hong Kong) · 2026Article
- A Review of Synthetic Bone Grafts in Lumbar Interbody Fusion.Bioengineering (Basel, Switzerland) · 2026Review
- Comparative Osteoinductive Potential of BMP-2, Bioactive Glass, and Demineralized Bone Matrix: An In Vitro Alkaline Phosphatase Assay Study.International journal of spine surgery · 2025Article
- Advancements in biomaterials and bioactive solutions for lumbar spine fusion cages: Current trends and future perspectives.Bioactive materials · 2025Review
- Transforming spinal surgery with innovations in biologics and additive manufacturing.Materials today. Bio · 2025Review
- Bone fusion materials: past, present, and future.Asian spine journal · 2025Article
- Osteogenic Potential and Bone Matrix Maturity: Comparison of Demineralized Bone Matrix and P15 Polypeptide iFactorMedicina (Kaunas, Lithuania) · 2025Article
- Universal Hydrogel Carrier Enhances Bone Graft Success: Preclinical and Clinical Evaluation.Advanced healthcare materials · 2025Article
- Experimental study on salmon demineralized bone matrix loaded with recombinant human bone morphogenetic protein-2:Open life sciences · 2025Article
- Research Progress of Bone Grafting: A Comprehensive Review.International journal of nanomedicine · 2025Review
- Use of allograft bone matrix in clinical orthopedics.Regenerative medicine · 2024Review
- Comparison of Fusion Rates among Various Demineralized Bone Matrices in Posterior Lumbar Interbody Fusion.Medicina (Kaunas, Lithuania) · 2024Article
- Demineralized Bone Matrix and Fibers in Spinal Fusion.International journal of spine surgery · 2023Article
- Outcomes of Arthroscopic Scaphoid Excision and Lunocapitate Fusion for Advanced Traumatic Arthritis of the Wrist.Clinics in orthopedic surgery · 2023Article
- Demineralized cortical fibers are associated with a low pseudarthrosis rate in patients undergoing surgery for adult spinal deformity without three-column osteotomy.Brain & spine · 2023Article
- Development of photoreactive demineralized bone matrix 3D printing colloidal inks for bone tissue engineering.Regenerative biomaterials · 2023Article
- The impact of demineralized bone matrix characteristics on pseudarthrosis and surgical outcomes after posterolateral lumbar decompression and fusion.Journal of craniovertebral junction & spineArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGraft augmentation for spinal fusion is an area of continued interest, with a wide variety of available products lacking clear recommendations regarding appropriate use. While iliac crest autograft has long been considered the "gold standard", suboptimal fusion rates along with harvest-related concerns continue to drive the need for graft alternatives. There are now multiple options of products with various characteristics that are available. These include demineralized bone matrix (DBM) and demineralized bone fibers (DBF), which have been used increasingly to promote spine fusion. The purpose of this review is to provide an updated narrative on the use of DBM/DBF in spine surgery.
methodsLiterature review.
resultsThe clinical application of DBM in spine surgery has evolved since its introduction in the mid-1900s. Early preclinical studies demonstrated its effectiveness in promoting fusion. When used in the cervical, thoracic, and lumbar spine, more recent clinical data suggest similar rates of fusion compared with autograft, although clinical studies are primarily limited to level III or IV evidence with few level I studies. However, significant variability in surgical technique and type of product used in the literature limits its interpretation and overall application.
conclusionsDBM and DBF are bone graft options in spine surgery. Most commonly used as graft extenders, they have the ability to increase the volume of traditional grafting techniques while potentially inducing new bone formation. While the literature supports good fusion rates when used in the lumbar spine and when used with adjuvant cages or additional grafting techniques in the cervical spine, care should be taken when using as a stand-alone product. As new literature emerges, DBM and DBF can be a useful method in a surgeon's armamentarium for fusion-based procedures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.