ReviewTrends in genetics : TIG2022
Regulatory mechanisms ensuring coordinated expression of functionally related genes.
Review in Trends in genetics : TIG, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- RNA-protein complexes as key regulators of plant secondary metabolism: Biophysical interactions and functional significance.Biochemistry and biophysics reports · 2026Review
- Article
- APOL1 risk genotypes influence DNA methylation across multiple genomic elements in APOL1-APOL4- MYH9 region in African Americans.Clinical epigenetics · 2026Article
- MEAST: a novel framework for analyzing gene set stability in single cell transcriptomics.Scientific reports · 2026Article
- Distinguishing causal from tagging enhancers using single-cell multiome data.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Spatial transcriptomics iterative hierarchical clustering (stIHC): A novel method for identifying spatial gene co-expression modules.Quantitative biology (Beijing, China) · 2025Article
- Interaction Between Enhancers and Promoters in Chicken Genome.International journal of molecular sciences · 2025Article
- Genome-wide identification and expression pattern analysis of the CPP transcription factor family in Medicago sativa L.BMC plant biology · 2025Article
- IsJournal of developmental biology · 2025Review
- CXCL Gene Clusters Regulated by Enhancer-Mediated DNA Looping Alteration in Pancreatic Cancer Cells.Journal of cellular and molecular medicine · 2025Article
- Accelerating crop improvement via integration of transcriptome-based network biology and genome editing.Planta · 2025Review
- Cortex-SpecificThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- DNA supercoiling modulates eukaryotic transcription in a gene-orientation dependent manner.bioRxiv : the preprint server for biology · 2025Article
- Identification and functional characterization of bidirectional gene pairs and their intergenic regions in cotton.BMC plant biology · 2024Article
- The essential role of architectural noncoding RNARNA (New York, N.Y.) · 2024Article
- Evidence of Nonrandom Patterns of Functional Chromosome Organization in Danaus plexippus.Genome biology and evolution · 2024Article
- Hidden features of NAD-RNA epitranscriptome iniScience · 2024Article
- Evolution of the gene regulatory network of body axis by enhancer hijacking in amphioxus.eLife · 2024Article
- Shared regulation and functional relevance of local gene co-expression revealed by single cell analysis.Communications biology · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Coordinated spatiotemporal expression of large sets of genes is required for the development and homeostasis of organisms. To achieve this goal, organisms use myriad strategies where they form operons, utilize bidirectional promoters, cluster genes, share enhancers among genes by DNA looping, and form topologically associated domains and transcriptional condensates. Coexpression achieved by these different strategies is hypothesized to have functional importance in minimizing gene expression variability, establishing dosage balance to ensure stoichiometry of protein complexes, and minimizing accumulation of toxic intermediate metabolites. By combining gene-editing tools with computational modeling, recent studies tested the advantages of adjacent genes located in pairs and clusters. We propose that with the advancement of gene editing, single-cell sequencing, and imaging tools, one could readily test the functional importance of different coexpression strategies in a variety of biological processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.