ArticleImplementation science communications2021
Identified barriers and facilitators to stroke risk screening in children with sickle cell anemia: results from the DISPLACE consortium.
Article in Implementation science communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Successful implementation of stroke risk screening for sickle cell anemia in the DISPLACE study: results of a cluster randomized trial.Implementation science : IS · 2025Trial
- Factors in the implementation of ASH SCD guidelines on silent cerebral infarcts and cognition at a single sickle cell center.Blood advances · 2026Article
- mHealth-Enabled Stroke Screening for Pediatric Sickle Cell Disease in Low-Resource Settings: Systematic Literature Review of Critical Barriers, Emerging Technologies, and AI-Driven Solutions.JMIR pediatrics and parenting · 2026Review
- Barriers to sickle cell disease care: a biopsychosocial analysis mapped to the standards of care guidelines by the sickle pan African research consortium.Journal of public health (Oxford, England) · 2026Article
- Barriers, facilitators and recommendations for the implementation of newborn sickle cell screening program in tribal communities: findings from a qualitative multicentric study in India.The Lancet regional health. Southeast Asia · 2025Article
- Sickle cell care and implementation science.Blood advances · 2025Article
- DISPLACE study shows poor quality of transcranial doppler ultrasound for stroke risk screening in sickle cell anemia.Blood advances · 2024Article
- Practice Patterns for Addressing Developmental-Behavioral Concerns in Sickle Cell Specialty Care.Clinical practice in pediatric psychology · 2023Article
- Prioritizing Sickle Cell Disease.Pediatrics · 2022Article
- Development and Process Evaluation of Sickle Stroke Screen: A Patient Educational Initiative to Improve Transcranial Doppler Screening in Sickle Cell Anemia.Journal of pediatric hematology/oncology nursingArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundChildren with sickle cell anemia are at risk for stroke. Ischemic stroke risk can be identified among children ages 2-16 years with sickle cell anemia using transcranial Doppler ultrasound. Despite strong recommendations for transcranial Doppler screening in guidelines released by the National Heart, Lung, and Blood Institute, implementation of transcranial Doppler screening in sickle cell anemia remains suboptimal. The purpose of this study was to identify barriers and facilitators to transcranial Doppler screening in a large national consortium to inform subsequent implementation interventions.
methodsA qualitative descriptive approach was used to conduct 52 semi-structured interviews with a sample of patients with sickle cell anemia, their parents or primary caregivers, and healthcare providers dispersed across the United States. Interviews took place from September 2018 through March 2019. Directed content analysis was conducted with an adapted version of the Multilevel Ecological Model of Health as an initial coding framework, completed July 2019. Frequency analysis was conducted to determine predominant barrier and facilitator themes.
resultsFourteen barrier themes and 12 facilitator themes emerged representing all levels of the ecological framework. Two barrier themes (Logistical Difficulties and Competing Life Demands and Gaps in Scheduling and Coordination), and 5 facilitator themes (Coordination, Scheduling and Reminders; Education and Information; Provider and Staff Investment and Assistance; Positive Patient Experience; and Convenient Location) were predominant.
conclusionsBarriers and facilitators to transcranial Doppler screening in children with sickle cell anemia are complex and occur across multiple ecological levels. One barrier theme and 3 facilitator themes were found to be optimal to address in subsequent implementation interventions.
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