ArticleBMC neurology2021
Prognostic factors of adult tuberculous meningitis in intensive care unit: a single-center retrospective study in East China.
Article in BMC neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Microbiological diagnosis and mortality of tuberculosis meningitis: Systematic review and meta-analysis.PloS one · 2023Pooled it
- Systematic review of tuberculous meningitis in high-risk populations: mortality and diagnostic disparities.Future microbiologyPooled it
- Contezolid in tuberculous meningitis: comparable efficacy and favorable safety.Frontiers in cellular and infection microbiology · 2026Article
- Article
- Predictors of Tuberculous Meningitis Mortality Among Persons with HIV in Mozambique.Tropical medicine and infectious disease · 2025Article
- Neuroimaging for prognosis of central nervous system infections: a systematic review and meta-analysis.Annals of intensive care · 2025Article
- Tuberculous Meningitis Across the Lifespan.The Journal of infectious diseases · 2025Review
- Convolutional neural network using magnetic resonance brain imaging to predict outcome from tuberculosis meningitis.PloS one · 2025Article
- Article
- A case report of tuberculous meningitis resulting in irreversible visual impairment due to delayed diagnosis.Clinical case reports · 2024Article
- Analysis of risk factors for long-term mortality in patients with stage II and III tuberculous meningitis.BMC infectious diseases · 2024Article
- Diagnosis and management of severe pulmonary and extrapulmonary tuberculosis in critically ill patients: A mini review for clinicians.World journal of critical care medicine · 2024Review
- Ventriculoperitoneal shunt for tuberculous meningitis-associated hydrocephalus: long-term outcomes and complications.BMC infectious diseases · 2023Article
- Association of blood neutrophil-lymphocyte ratio with short-term prognosis and severity of tuberculosis meningitis patients without HIV infection.BMC infectious diseases · 2023Article
- Correction to: Prognostic factors of adult tuberculous meningitis in intensive care unit: a single-center retrospective study in East China.BMC neurology · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
Abstract
backgroundTuberculous meningitis (TBM) is the most lethal form of tuberculosis worldwide. Data on critically ill TBM patients in the intensive care unit (ICU) of China are lacking. We tried to identify prognostic factors of adult TBM patients admitted to ICU in China.
methodsWe conducted a retrospective study on adult TBM in ICU between January 2008 and April 2018. Factors associated with unfavorable outcomes at 28 days were identified by logistic regression. Factors associated with 1-year mortality were studied by Cox proportional hazards modeling.
resultsEighty adult patients diagnosed with TBM (age 38.5 (18-79) years, 45 (56 %) males) were included in the study. An unfavorable outcome was observed in 39 (49 %) patients and were independently associated with Acute Physiology and Chronic Health Evaluation (APACHE) II > 23 (adjusted odds ratio (aOR) 5.57, 95 % confidence interval (CI) 1.55-19.97), Sequential Organ Failure Assessment (SOFA) > 8 (aOR 9.74, 95 % CI 1.46-64.88), and mechanical ventilation (aOR 18.33, 95 % CI 3.15-106.80). Multivariate Cox regression analysis identified two factors associated with 1-year mortality: APACHE II > 23 (adjusted hazard ratio (aHR) 4.83; 95 % CI 2.21-10.55), and mechanical ventilation (aHR 9.71; 95 % CI 2.31-40.87).
conclusionsFor the most severe adult TBM patients of Medical Research Council (MRC) stage III, common clinical factors aren't effective enough to predict outcomes. Our study demonstrates that the widely used APACHE II and SOFA scores on admission can be used to predict short-term outcomes, while APACHE II could also be used to predict long-term outcomes of adult patients with TBM in ICU.
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