Evidence map›Paper›PMID 34376147›Full record

ArticleBMC infectious diseases2021

Establishment of a novel scoring model for mortality risk prediction in HIV-infected patients with cryptococcal meningitis.

Ting Zhao, Xiao-Lei Xu, Jing-Min Nie, Xiao-Hong Chen, Zhong-Sheng Jiang, Shui-Qing Liu, Tong-Tong Yang, Xuan Yang, Feng Sun, Yan-Qiu Lu and 2 more

Abstract readMulticenter Study
In one paragraph

Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Molecular Diagnostics ofDiseases (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ting Zhao *Division of Infectious Diseases, Chongqing Public Health Medical Center, 109 Baoyu Road, Shapingba, Chongqing, 400036, China.
Xiao-Lei Xu *Division of Infectious Diseases, Chongqing Public Health Medical Center, 109 Baoyu Road, Shapingba, Chongqing, 400036, China.
Jing-Min NieDivision of Infectious Diseases, Chongqing Public Health Medical Center, 109 Baoyu Road, Shapingba, Chongqing, 400036, China.
Xiao-Hong ChenDepartment of Infectious Diseases, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang province, China.
Zhong-Sheng JiangDivision of Infectious Diseases, Liuzhou People's Hospital, Liuzhou, Guangxi province, China.
Shui-Qing LiuDepartment of Infectious Diseases, Guiyang Public Health Clinical Center, Guiyang, Guizhou province, China.
Tong-Tong YangDepartment of Infectious Disease, Public Health Clinical Center of Chengdu, Chengdu, Sichuan province, China.
Xuan YangDepartment of Infectious Diseases, Sixth People's Hospital of Zhengzhou, Zhengzhou, Henan province, China.
Feng SunDivision of Infectious Diseases, Chongqing Public Health Medical Center, 109 Baoyu Road, Shapingba, Chongqing, 400036, China.
Yan-Qiu LuDivision of Infectious Diseases, Chongqing Public Health Medical Center, 109 Baoyu Road, Shapingba, Chongqing, 400036, China.
Vijay HarypursatDivision of Infectious Diseases, Chongqing Public Health Medical Center, 109 Baoyu Road, Shapingba, Chongqing, 400036, China.
Yao-Kai ChenDivision of Infectious Diseases, Chongqing Public Health Medical Center, 109 Baoyu Road, Shapingba, Chongqing, 400036, China. yaokaichen@hotmail.com.ORCID http://orcid.org/0000-0002-9427-1367

Funding

the Capacity Improvement Plan Project of Units appointed by the Chongqing Municipal Health Commission 2019NLTS003the Joint Medical Research Project of Chongqing Municipal Science and Technology Bureau and Chongqing Municipal Health Commission 2019ZDXM012the National Science and Technology Major Project of China During the 13th Five-year Plan Period 2018ZX10302104Youth Scientific Research and Innovation Fund Project of Chongqing Public Health Medical Center 2019QNKYXM05
6 · The paper itself

Abstract

backgroundCryptococcal meningitis (CM) remains a leading cause of death in HIV-infected patients, despite advances in CM diagnostic and therapeutic strategies. This study was performed with the aim to develop and validate a novel scoring model to predict mortality risk in HIV-infected patients with CM (HIV/CM).

methodsData on HIV/CM inpatients were obtained from a Multicenter Cohort study in China. Independent risk factors associated with mortality were identified based on data from 2013 to 2017, and a novel scoring model for mortality risk prediction was established. The bootstrapping statistical method was used for internal validation. External validation was performed using data from 2018 to 2020.

resultsWe found that six predictors, including age, stiff neck, impaired consciousness, intracranial pressure, CD4

conclusionsOur developed scoring model of six variables is simple, convenient, and accurate for screening high-risk patients with HIV/CM, which may be a useful tool for physicians to assess prognosis in HIV/CM inpatients.

Indexed as

HIV InfectionsMeningitis, CryptococcalCohort StudiesHumansMass ScreeningRisk FactorsCryptococcal meningitisHIVMortalityRisk factorsScoring model

Identifiers

PMID34376147
PMCPMC8353436

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.