Evidence map›Paper›PMID 34376057›Full record

ArticleHuman gene therapy2021

Johanna E Wagner, Lena Zobel, Maximilian J Gerhardt, Catherine R O'Riordan, Amy Frederick, Simon M Petersen-Jones, Martin Biel, Stylianos Michalakis

Open access · greenAbstract read
In one paragraph

Article in Human gene therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Development of a translatable gene augmentation therapy for CNGB1-retinitis pigmentosa.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Johanna E WagnerDepartment of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany.
Lena ZobelDepartment of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany.
Maximilian J GerhardtDepartment of Ophthalmology, University Hospital, LMU Munich, Munich, Germany.
Catherine R O'RiordanGene Therapy, Rare Diseases, Sanofi, Framingham, Massachusetts, USA.
Amy FrederickGene Therapy, Rare Diseases, Sanofi, Framingham, Massachusetts, USA.
Simon M Petersen-JonesVeterinary Medical Center, Michigan State University, East Lansing, Michigan, USA.
Martin BielDepartment of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany.
Stylianos MichalakisDepartment of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID 0000-0001-5092-9238
LMU Klinikum · DELudwig-Maximilians-Universität München · DESanofi (France) · FRMichigan State University · US

Funding

Translational Gene Therapy for CNGB1 Retinitis PigmentosaR24EY027285 · NEI · MICHIGAN STATE UNIVERSITY · PI HAUSWIRTH, WILLIAM W, MICHALAKIS, STYLIANOS · 2018 to 2022
$8.6M
NEI NIH HHS R24 EY027285
6 · The paper itself

Abstract

Retinitis pigmentosa type 45 (RP45) is an autosomal-recessively inherited blinding disease caused by mutations in the cyclic nucleotide-gated channel subunit beta 1 (

Indexed as

Retinitis PigmentosaAnimalsCyclic Nucleotide-Gated Cation ChannelsDependovirusGenetic TherapyMiceMice, KnockoutNerve Tissue ProteinsRetinaRhodopsinCnga1 protein, mouseCngb1 protein, mouseCyclic Nucleotide-Gated Cation ChannelsNerve Tissue ProteinsRhodopsinAAVadeno-associated virusCNGB1retinal gene therapyretinitis pigmentosa

Identifiers

PMID34376057
PMCPMC8819509
OpenAlexW3189169221

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.