Evidence map›Paper›PMID 34375749›Full record

Trial reportContemporary clinical trials2021

Sense2Stop: A micro-randomized trial using wearable sensors to optimize a just-in-time-adaptive stress management intervention for smoking relapse prevention.

Samuel L Battalio, David E Conroy, Walter Dempsey, Peng Liao, Marianne Menictas, Susan Murphy, Inbal Nahum-Shani, Tianchen Qian, Santosh Kumar, Bonnie Spring

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Contemporary clinical trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07067151 enrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Use of Noninvasive Wearables Biomonitoring to Detect Pre-Smoking, Smoking, And Post-Smoking Stages: An Observational Laboratory Study

TypeobservationalSponsorNational Institute on Minority Health and Health Disparities (NIMHD)Ran2026 to 2028Enrolled30ConditionsSmoking
NCT07746492 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Digital Real-Time Support for Stress-Induced Smoking and Unhealthy Eating Among Gender and Sexual Minorities in Dhaka

TypeinterventionalSponsorInternational Centre for Diarrhoeal Disease Research, BangladeshRan2026 to 2027Enrolled115ConditionsTobacco Use, Electronic Cigarette Use, Emotional Eating, Stress, PsychologicalArmsJust-in-Time Adaptive Support Message
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Article
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  9. Replicable Bandits for Digital Health Interventions.Statistical science : a review journal of the Institute of Mathematical Statistics · 2025
    Article
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  12. Reinforcement Learning on Dyads to Enhance Medication Adherence.Artificial intelligence in medicine. Conference on Artificial Intelligence in Medicine (2005- ) · 2025
    Article
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  14. Review
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  19. HabitSense: A Privacy-Aware, AI-Enhanced Multimodal Wearable Platform for mHealth Applications.Proceedings of the ACM on interactive, mobile, wearable and ubiquitous technologies · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Samuel L BattalioDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N. Lakeshore Drive, Suite 1400, Chicago, IL 60611, United States of America.
David E ConroyDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N. Lakeshore Drive, Suite 1400, Chicago, IL 60611, United States of America; Department of Kinesiology, Penn State University, 266 Recreation Building, University Park, PA 16802, United States of America.
Walter DempseySurvey Research Center, University of Michigan, 426 Thompson Street, Room 2464, Ann Arbor, MI 48106, United States of America.
Peng LiaoDepartment of Statistics, Harvard University, Science Center 400 Suite, One Oxford Street, Cambridge, MA 02138, United States of America.
Marianne MenictasDepartment of Statistics, Harvard University, Science Center 400 Suite, One Oxford Street, Cambridge, MA 02138, United States of America.
Susan MurphyDepartment of Statistics, Harvard University, Science Center 400 Suite, One Oxford Street, Cambridge, MA 02138, United States of America.
Inbal Nahum-ShaniSurvey Research Center, University of Michigan, 426 Thompson Street, Room 2464, Ann Arbor, MI 48106, United States of America.
Tianchen QianDepartment of Statistics, University of California, Irvine, Irvine, CA 92697, United States of America.
Santosh KumarDepartment of Computer Science, University of Memphis, 319 Dunn Hall, Memphis, TN 38152, United States of America.
Bonnie SpringDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N. Lakeshore Drive, Suite 1400, Chicago, IL 60611, United States of America. Electronic address: bspring@northwestern.edu.
Harvard University Press · USNorthwestern University · USUniversity of Michigan · USUniversity of California, Irvine · USUniversity of Memphis · US

Funding

Pilot and Mentoring CoreP50DA054039 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LINDA M COLLINS, SUSAN A MURPHY · 2021 to 2026
$18.2M
TRAINING U54EB020404 · NIBIB · UNIVERSITY OF MEMPHIS · PI KUMAR, SANTOSH · 2014 to 2018
$11.3M
TR&D3 - Rapid Translation of AI-powered Temporally Precise mHealth Interventions via Efficient and Embeddable Trustworthy Biomarker ImplementationsP41EB028242 · NIBIB · UNIVERSITY OF MEMPHIS · PI Santosh Kumar · 2020 to 2026
$9.5M
Novel Methods for Intensive Longitudinal Data in SMART Studies of Drug Abuse and HIVR01DA039901 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALMIRALL, DANIEL, NAHUM-SHANI, INBAL BILLIE · 2015 to 2024
$5.4M
SMART Weight Loss ManagementR01DK108678 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI NAHUM-SHANI, INBAL BILLIE, SPRING, BONNIE · 2016 to 2020
$3.5M
Novel use of mHealth data to identify states of vulnerability and receptivity to JITAIs SupplementU01CA229437 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NAHUM-SHANI, INBAL BILLIE, WETTER, DAVID W · 2018 to 2022
$2.8M
Data-Based Methods for Just-In-Time Adaptive Interventions in Alcohol UseR01AA023187 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MURPHY, SUSAN A · 2015 to 2019
$2.6M
SMARTer weight loss managementR01DK134629 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Bonnie Spring · 2023 to 2026
$2.3M
Methodological and data-driven approach to infer durable behavior change from mHealth dataR01DK125414 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HEDEKER, DONALD, SPRING, BONNIE · 2020 to 2023
$2.0M
NCI NIH HHS U01 CA229437NIAAA NIH HHS R01 AA023187NIBIB NIH HHS P41 EB028242NIBIB NIH HHS U54 EB020404NIDA NIH HHS P50 DA054039NIDA NIH HHS R01 DA039901NIDDK NIH HHS R01 DK108678NIDDK NIH HHS R01 DK125414NIDDK NIH HHS R01 DK134629
6 · The paper itself

Abstract

backgroundRelapse to smoking is commonly triggered by stress, but behavioral interventions have shown only modest efficacy in preventing stress-related relapse. Continuous digital sensing to detect states of smoking risk and intervention receptivity may make it feasible to increase treatment efficacy by adapting intervention timing.

objectiveAims are to investigate whether the delivery of a prompt to perform stress management behavior, as compared to no prompt, reduces the likelihood of (a) being stressed and (b) smoking in the subsequent two hours, and (c) whether current stress moderates these effects. STUDY

designA micro-randomized trial will be implemented with 75 adult smokers who wear Autosense chest and wrist sensors and use the mCerebrum suite of smartphone apps to report and respond to ecological momentary assessment (EMA) questions about smoking and mood for 4 days before and 10 days after a quit attempt and to access a set of stress-management apps. Sensor data will be processed on the smartphone in real time using the cStress algorithm to classify minutes as probably stressed or probably not stressed. Stressed and non-stressed minutes will be micro-randomized to deliver either a prompt to perform a stress management exercise via one of the apps or no prompt (2.5-3 stress management prompts will be delivered daily). Sensor and self-report assessments of stress and smoking will be analyzed to optimize decision rules for a just-in-time adaptive intervention (JITAI) to prevent smoking relapse. SIGNIFICANCE: Sense2Stop will be the first digital trial using wearable sensors and micro-randomization to optimize a just-in-time adaptive stress management intervention for smoking relapse prevention.

Indexed as

Smoking CessationWearable Electronic DevicesAdultHumansRecurrenceSecondary PreventionSmokingSmoking PreventionDigital interventionJust-in-time adaptive interventionmHealthMicro-randomized trialOptimizationSmokingStress

Identifiers

PMID34375749
PMCPMC8556307
OpenAlexW3191219846

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.