Evidence map›Paper›PMID 34375690›Full record

ReviewJournal of controlled release : official journal of the Controlled Release Society2021

Nanomedicine based approaches for combating viral infections.

Saurabh Shah, Mahavir Bhupal Chougule, Arun K Kotha, Rama Kashikar, Chandraiah Godugu, Rajeev Singh Raghuvanshi, Shashi Bala Singh, Saurabh Srivastava

Abstract readReview
In one paragraph

Review in Journal of controlled release : official journal of the Controlled Release Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Saurabh ShahDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India.
Mahavir Bhupal ChouguleDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, MS, USA; Department Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA 30341, USA.
Arun K KothaDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, MS, USA; Department Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA 30341, USA.
Rama KashikarDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, MS, USA; Department Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA 30341, USA.
Chandraiah GoduguDepartment of Biological Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India.
Rajeev Singh RaghuvanshiIndian Pharmacopoeia Commission, Ministry of Health & Family Welfare, Government of India, India.
Shashi Bala SinghDepartment of Biological Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India.
Saurabh SrivastavaDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India. Electronic address: saurabh@niperhyd.ac.in.

Funding

Receptor-Guided Targeted Therapy for AsthmaR15HL138718 · NHLBI · UNIVERSITY OF MISSISSIPPI · PI CHOUGULE, MAHAVIR B · 2018 to 2018
$455k
NHLBI NIH HHS R15 HL138718
6 · The paper itself

Abstract

Millions of people die each year from viral infections across the globe. There is an urgent need to overcome the existing gap and pitfalls of the current antiviral therapy which include increased dose and dosing frequency, bioavailability challenges, non-specificity, incidences of resistance and so on. These stumbling blocks could be effectively managed by the advent of nanomedicine. Current review emphasizes over an enhanced understanding of how different lipid, polymer and elemental based nanoformulations could be potentially and precisely used to bridle the said drawbacks in antiviral therapy. The dawn of nanotechnology meeting vaccine delivery, role of RNAi therapeutics in antiviral treatment regimen, various regulatory concerns towards clinical translation of nanomedicine along with current trends and implications including unexplored research avenues for advancing the current drug delivery have been discussed in detail.

Indexed as

NanomedicineVirus DiseasesDrug Delivery SystemsHumansNanotechnologyPolymersPolymersAntiviralbarriersnanomedicinenanovaccineRNAi

Identifiers

PMID34375690
PMCPMC8526416

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.